Methyl 6-O-β-D-galactopyranosyl-α-D-galactopyranoside | 111002-20-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 6-O-β-D-galactopyranosyl-α-D-galactopyranoside
• 英文别名: Gal(b1-6)a-Gal1Me；(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methoxy]oxane-3,4,5-triol
• CAS: 111002-20-1
• 化学式: C₁₃H₂₄O₁₁
• 分子量: 356.327
• InChiKey: ZQPVHVKWCGZNDW-KKDFNLRASA-N

物化性质

• 沸点：
  644.0±55.0 °C(Predicted)
• 密度：
  1.63±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  179
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  Allyl β-D-galactopyranoside 、 Α-D-乳酸吡喃糖苷甲酯 在 β-galactosidase from Aspergillus oryzae 、 acetate buffer 作用下， 反应 78.0h， 以67%的产率得到Methyl 6-O-β-D-galactopyranosyl-α-D-galactopyranoside
  参考文献：
  名称：

  β-Galactosidase transferase activity in ice and use of vinyl-β-d-galactoside as donor

  摘要：

  The ability of vinyl-beta-D-galactoside as a donor in transglycosylation reactions catalysed by the beta-glycosidase from Aspergillus oryzae using allylic alcohol and methyl-alpha-galactoside as accepters is tested. A kinetic study made in comparison with another donor, the 2-nitrophenyl-beta-D-galactoside, shows that the use of the latter leads at room temperature to better yields than those obtained from the former. A reverse situation is observed in ice at -7 degrees C, conditions in which the yield for transglycosylation can be enhanced from 59% to 82% with methyl-alpha-galactoside as an acceptor. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00194-8

文献信息

• Immobilisation of β-d-galactosidase from Escherichia coli on cellulose beads and its use for the synthesis of disaccharide derivatives
  作者：Vladimír Kéry、Štefan Kučár、Mária Matulová、Jana Haplová

  DOI：10.1016/0008-6215(91)80146-e

  日期：1991.1

  beta-D-Galactosidase, isolated from cloned E. coli, was immobilised on cellulose beads via oxidation with sodium periodate, activation by cyanuric chloride, or diazotisation. beta-D-Galactosidase immobilised via azo bonds showed the highest relative activity and thermostability, and was used for synthesis of disaccharide methyl glycosides.

  从克隆的大肠杆菌中分离出的β-D-半乳糖苷酶通过高碘酸钠氧化，氰尿酰氯活化或重氮化而固定在纤维素珠上。通过偶氮键固定的β-D-半乳糖苷酶显示出最高的相对活性和热稳定性，并用于合成二糖甲基糖苷。
• MacManus, David A.; Grabowska, Urszula; Biggadike, Keith, Journal of the Chemical Society. Perkin transactions I, 1999, # 3, p. 295 - 305
  作者：MacManus, David A.、Grabowska, Urszula、Biggadike, Keith、Bird, Michael I.、Davies, Stephen、Vulfson, Evgeny N.、Gallagher, Timothy

  DOI：——

  日期：——
• β-Galactosidase transferase activity in ice and use of vinyl-β-d-galactoside as donor
  作者：V. Chiffoleau-Giraud、P. Spangenberg、C. Rabiller

  DOI：10.1016/s0957-4166(97)00194-8

  日期：1997.6

  The ability of vinyl-beta-D-galactoside as a donor in transglycosylation reactions catalysed by the beta-glycosidase from Aspergillus oryzae using allylic alcohol and methyl-alpha-galactoside as accepters is tested. A kinetic study made in comparison with another donor, the 2-nitrophenyl-beta-D-galactoside, shows that the use of the latter leads at room temperature to better yields than those obtained from the former. A reverse situation is observed in ice at -7 degrees C, conditions in which the yield for transglycosylation can be enhanced from 59% to 82% with methyl-alpha-galactoside as an acceptor. (C) 1997 Elsevier Science Ltd.