(Z)-1,3,5-triphenylpent-2-en-4-ynyl acetate | 1126271-02-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (Z)-1,3,5-triphenylpent-2-en-4-ynyl acetate
• 英文别名: [(Z)-1,3,5-triphenylpent-2-en-4-ynyl] acetate
• CAS: 1126271-02-0
• 化学式: C₂₅H₂₀O₂
• 分子量: 352.433
• InChiKey: CIRPTRFMTGHYPR-LYBHJNIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-1,3,5-triphenylpent-2-en-4-ynyl acetate 在 palladium(II) acetylacetonate 、 三(五氟苯基)膦 、 copper dichloride 作用下， 以 1,4-二氧六环 为溶剂， 以46%的产率得到(3-chlorocyclopenta-1,3-diene-1,2,4-triyl)tribenzene
  参考文献：
  名称：

  钯催化（Z）-2-En-4-yn乙酸盐与N-甲基吲哚的钯催化合成四取代的环戊二烯

  摘要：

  开发了一种有效的方法，该方法通过Pd催化（Z）-2-en-4-yn乙酸盐与取代的吲哚的Pd催化合成四取代的环戊二烯。该方法的优点是范围广，条件简单和容易获得的起始原料。

  DOI：

  10.1021/jo3021055
• 作为产物：
  描述：

  1,3,5-triphenylpent-2-en-4-yn-1-ol 、 乙酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (Z)-1,3,5-triphenylpent-2-en-4-ynyl acetate
  参考文献：
  名称：

  Efficient synthesis of highly substituted pyrroles based on the tandem reactions: intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation

  摘要：

  A novel and efficient method for construction of polysubstituted pyrroles, which included an intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation, was developed. It was found that the reactions gave high yields (55-92%). Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.12.018

文献信息

• Bi(III)-Catalyzed Intermolecular Reactions of (<i>Z</i>)-Pent-2-en-4-yl Acetates with Ethynylarenes for the Construction of Multisubstituted Fluorene Skeletons through a Cascade Electrophilic Addition/Cycloisomerization Sequence
  作者：Xiang-Chuan Wang、Ru-Long Yan、Mei-Jin Zhong、Yong-Min Liang

  DOI：10.1021/jo202607z

  日期：2012.2.17

  A Bi(III)-catalyzed method for the synthesis of highly conjugated aromatic multisubstituted fluorene with (Z)-pent-2-en-4-yl acetates and ethynylarenes via domino reaction is described. In this process, the reaction appears to be very general and suitable for a variety of multisubstituted fluorene.

  描述了一种Bi（III）催化的方法，该方法通过多米诺反应与（Z）-戊-2-烯-2-基乙酸酯和乙炔基芳烃合成高度共轭的芳族多取代芴。在此过程中，反应似乎非常普遍，适用于多种多取代芴。
• Efficient synthesis of highly substituted pyrroles based on the tandem reactions: intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation
  作者：Yong-Jiang Bian、Xue-Yuan Liu、Ke-Gong Ji、Xing-Zhong Shu、Li-Na Guo、Yong-Min Liang

  DOI：10.1016/j.tet.2008.12.018

  日期：2009.2

  A novel and efficient method for construction of polysubstituted pyrroles, which included an intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation, was developed. It was found that the reactions gave high yields (55-92%). Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
• Synthesis of Tetrasubstituted Cyclopentadienes via Palladium-Catalyzed Reaction of (<i>Z</i>)-2-En-4-yn Acetates and <i>N</i>-Methyl Indoles
  作者：Mei-Jin Zhong、Xiang-Chuan Wang、Hai-Tao Zhu、Jie Hu、Lei Liu、Xue-Yuan Liu、Yong-Min Liang

  DOI：10.1021/jo3021055

  日期：2012.12.7

  An efficient approach for the synthesis of tetrasubstituted cyclopentadienes through Pd-catalyzed reactions of (Z)-2-en-4-yn acetates with substituted indoles was developed. This methodology has the advantages of broad scope, simple conditions and easily accessible starting materials.

  开发了一种有效的方法，该方法通过Pd催化（Z）-2-en-4-yn乙酸盐与取代的吲哚的Pd催化合成四取代的环戊二烯。该方法的优点是范围广，条件简单和容易获得的起始原料。