(1-Propyl-cyclohexyl)-methanol | 85003-56-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1-Propyl-cyclohexyl)-methanol
• 英文别名: (1-Propylcyclohexyl)methanol
• CAS: 85003-56-1
• 化学式: C₁₀H₂₀O
• 分子量: 156.268
• InChiKey: BLTWBKKGNBVMNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1-Propyl-cyclohexyl)-methanol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 1-Formyl-1-propyl-cyclohexan
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8
• 作为产物：
  描述：

  1-propylcyclohexane-1-carboxylic acid 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 3.5h， 生成 (1-Propyl-cyclohexyl)-methanol
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8

文献信息

• Studies on antidiabetic agents. II. Synthesis of 5-(4-(1-methylcyclohexylmethoxy)-benzyl)thiazolidine-2,4-dione (ADD-3878) and its derivatives.
  作者：TAKASHI SOHDA、KATSUTOSHI MIZUNO、EIKO IMAMIYA、YASUO SUGIYAMA、TAKESHI FUJITA、YUTAKA KAWAMATSU

  DOI：10.1248/cpb.30.3580

  日期：——

  More than 100 5-substituted thiazolidine-2, 4-diones were prepared and their hypoglycemic and hypolipidemic activities were evaluated with genetically obese and diabetic mice, yellow KK. The structure-activity relationship study showed that the 5-(4-oxybenzyl) moiety is essential for substantial activity. Among these compounds, 5-(4-cyclohexylmethoxy) benzylthiazolidine-2, 4-dione (47), 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2, 4-dione (49, ADD-3878) and 5-4-[2-(3-pyridyl) ethoxy] benzyl} thiazolidine-2, 4-dione (59) exhibited the most favorable properties in terms of activity and toxicity.

  合成了100多种5-取代的噻唑烷-2,4-二酮类化合物，并通过遗传性肥胖和糖尿病小鼠（KK黄色小鼠）评估了它们的降血糖和降血脂活性。结构-活性关系研究表明，5-(4-羟基苄基)部分对于显著活性是必要的。在这些化合物中，5-(4-环己基甲氧基)苄基噻唑烷-2,4-二酮（47）、5-[4-(1-甲基环己基甲氧基)苄基]-噻唑烷-2,4-二酮（49，ADD-3878）和5-4-[2-(3-吡啶基)乙氧基]苄基}噻唑烷-2,4-二酮（59）在活性和毒性方面表现出最佳特性。
• Ferroelectric chiral smectic liquid crystal composition and liquid crystal device using same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0347940A2

  公开（公告）日：1989-12-27

  A ferroelectric chiral smectic liquid crystal composition, comprising: at least one optically active compound represented by the following formula (II): wherein R3 denotes a linear or branched alkyl group having 1 - 18 carbon atoms capable of having a substituent; X3 denotes a single bond, -O- or Z1 denotes a single bond or or and m is 1 - 12; at least one compound represented by the following formula (III): wherein R4 and Rs respectively denote a linear or branched alkyl group having 1 - 18 carbon atoms capable of having a substituent, at lease one of R4 and Rs being optically active; X4 denotes a single bond, and X5 denotes a single bond, and at least one compound represented by the following formula (I) or (IV): wherein R, and R2 respectively denote a linear or branched alkyl group having 1 - 18 carbon atoms capable of having a substituent of C1 - C12 alkoxy group; X, and X2 respectively denote a single bond, wherein R6 and R7 respectively denote a linear or branched alkyl group having 1 - 18 carbon atoms capable of having a substituent; X6 and X7 respectively denote a single bond, Z2 denotes -CH20-, -OCH2- or a single bond;respectively denote denotes with proviso that at least one of

  一种铁电手性谱液晶组合物，包括： 至少一种由下式 (II) 代表的光学活性化合物： 其中，R3 表示具有 1 - 18 个碳原子的直链或支链烷基，可具有取代基； X3 表示单键、-O-或 Z1 表示单键或 或 m为1-12；至少一种由下式(III)代表的化合物： 其中 R4 和 Rs 分别表示具有 1-18 个碳原子的直链或支链烷基，可具有取代基，R4 和 Rs 中至少有一个具有光学活性；X4 表示单键、 和 X5 表示单键、 以及至少一种由下式（I）或（IV）代表的化合物： 其中 R 和 R2 分别表示具有 1 - 18 个碳原子的直链或支链烷基，可具有 C1 - C12 烷氧基的取代基；X 和 X2 分别表示单键、 其中 R6 和 R7 分别表示具有 1 - 18 个碳原子并可具有取代基的直链或支链烷基；X6 和 X7 分别表示单键、 Z2 表示 -CH20-、-OCH2- 或单键；分别表示 表示 但至少有一个
• Liquid crystal composition and liquid crystal device using same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0326086A2

  公开（公告）日：1989-08-02

  A liquid crystal composition comprises at least one compound represented by the formula [I] below and at least one compound represented by the formula [II] below: wherein R1 denotes an alkyl group having 1 - 16 carbon atoms capable of having a substituent; R2 denotes any one of alkyl group, alkoxy group, alkoxycarbonyl group, acyloxy group and alkoxycarbonyloxy group, each having 1 - 16 carbon atoms and being capable of having a substituent; and A denotes any one of and each capable of having a substituent; and wherein R3 denotes a linear alkyl group having 1 - 16 carbon atoms; R4 denotes a linear alkyl group having 1 - 12 carbon atoms; X1 is a single bond, -0-, or or

  一种液晶组合物包含至少一种由下式[I]表示的化合物和至少一种由下式[II]表示的化合物： 其中 R1 表示具有 1 - 16 个碳原子并可具有取代基的烷基；R2 表示烷基、烷氧基、烷氧羰基、酰氧基和烷氧羰氧基中的任一种，每个基团都具有 1 - 16 个碳原子并可具有取代基；A 表示以下任一种：烷基、烷氧基、烷氧羰基、酰氧基和烷氧羰氧基。 其中 R3 表示直链烷烃基团，R4 表示烷烃基团，R5 表示烷烃基团，R6 表示烷烃基团。 其中 R3 表示具有 1-16 个碳原子的直链烷基；R4 表示具有 1-12 个碳原子的直链烷基；X1 是单键、-0-、 或 或
• Liquid crystal composition and liquid crystal device containing same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0541509A2

  公开（公告）日：1993-05-12

  A ferroelectric chiral smectic liquid crystal composition is provided with a fast response speed and a less temperature dependency of the response speed by containing at least one mesomorphic compound represented by the formula (1) below: wherein R1 denotes an alkyl group having 1 - 16 carbon atoms and capable of having a substituent; R2 denotes an alkyl group, alkoxy group, alkoxycarbonyl group, acyloxy group or alkoxycarbonyloxy group each having 1 - 16 carbon atoms and capable of having a substituent; and respectively denotes each capable of having a substituent.

  通过含有至少一种由下式 (1) 表示的介形态化合物，铁电手性共晶液晶组合物具有快速响应速度和较小的响应速度温度依赖性： 其中 R1 表示具有 1 - 16 个碳原子且可具有取代基的烷基；R2 表示各自具有 1 - 16 个碳原子且可具有取代基的烷基、烷氧基、烷氧羰基、酰氧基或烷氧羰氧基；以及 R3 表示具有 1 - 16 个碳原子且可具有取代基的烷基、烷氧基、烷氧羰基、酰氧基或烷氧羰氧基。 分别表示 每个基团都可以有一个取代基。
• Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
  申请人：Bellenie Benjamin Richard

  公开号：US10004732B2

  公开（公告）日：2018-06-26

  The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

  本发明提供了抑制 PI 3-kinase gamma 异构体活性的式 (I) 化合物，可用于治疗由 PI 3-kinase gamma 异构体活化介导的疾病。