4-(4-Prop-2-enoxyphenoxy)phenol | 114896-77-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-Prop-2-enoxyphenoxy)phenol
• CAS: 114896-77-4
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: KOHCGXXPVLHZIW-UHFFFAOYSA-N

物化性质

• 熔点：
  71-73 °C
• 沸点：
  387.4±32.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-Prop-2-enoxyphenoxy)phenol 在 palladium on activated charcoal 氢气 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 邻二氯苯 为溶剂， 生成 Hydroxy-(3-{3-[4-(4-hydroxy-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester
  参考文献：
  名称：

  5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents

  摘要：

  A novel series of 5-aryl tliiazolidine-2,4-diones based dual PPARalpha/gamma agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00505-5
• 作为产物：
  描述：

  4-(4-羟基苯氧基)苯甲醛 在 potassium carbonate 、 间氯过氧苯甲酸 作用下， 以 丙酮 为溶剂， 生成 4-(4-Prop-2-enoxyphenoxy)phenol
  参考文献：
  名称：

  5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents

  摘要：

  A novel series of 5-aryl tliiazolidine-2,4-diones based dual PPARalpha/gamma agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00505-5

文献信息

• Cyanato Group-Containing Cyclic Phosphazene Compound and Method for Producing The Same
  申请人：Tada Yuji

  公开号：US20090170983A1

  公开（公告）日：2009-07-02

  A phosphazene compound, which can effectively enhance flame retardancy without deteriorating mechanical properties of a resin molded product, and is also less likely to deteriorate thermal reliability and dielectric properties, is represented by the formula (1) shown below. n represents an integer of 3 to 15. wherein A represents a group selected from the group consisting of an alkoxy group, an aryloxy group and a group having a cyanato group, and at least one is a group having a cyanato group, and an example of A is a cyanatophenyl-substituted phenyloxy group represented by the formula (4) shown below, and Y in the formula (4) represents O, S, SO 2 , CH 2 , CHCH 3 , C(CH 3 ) 2 , C(CF 3 ) 2 , C(CH 3 )CH 2 CH 3 or CO.
• US7442801B2
  申请人：——

  公开号：US7442801B2

  公开（公告）日：2008-10-28
• US7767739B2
  申请人：——

  公开号：US7767739B2

  公开（公告）日：2010-08-03
• 5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents
  作者：Ranjit C. Desai、Wei Han、Edward J. Metzger、Jeffrey P. Bergman、Dominick F. Gratale、Karen L. MacNaul、Joel P. Berger、Thomas W. Doebber、Kwan Leung、David E. Moller、James V. Heck、Soumya P. Sahoo

  DOI：10.1016/s0960-894x(03)00505-5

  日期：2003.8

  A novel series of 5-aryl tliiazolidine-2,4-diones based dual PPARalpha/gamma agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia. (C) 2003 Elsevier Ltd. All rights reserved.