3,4:5,6-di-O-isopropylidene-D-<1-11C>-arabino-hex-1-enitol | 214275-66-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,4:5,6-di-O-isopropylidene-D-<1-11C>-arabino-hex-1-enitol
• 英文别名: (4S,5R)-4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-(211C)ethenyl-2,2-dimethyl-1,3-dioxolane
• CAS: 214275-66-8
• 化学式: C₁₂H₂₀O₄
• 分子量: 227.277
• InChiKey: ZKJMHSUXOZFJAB-DVEPZGGDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,4:5,6-di-O-isopropylidene-D-<1-11C>-arabino-hex-1-enitol 在 水 、 palladium dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.07h， 生成
  参考文献：
  名称：

  Oegren, M.; Langstroem, B., Journal of labelled compounds and radiopharmaceuticals, 1997, vol. 40, p. 801 - 806

  摘要：

  DOI：
• 作为产物：
  描述：

  Methyltriphenylphosphonium iodide, (methyl-11C) 、 2,3-二氟-6-硝基苯胺 反应 0.07h， 生成 3,4:5,6-di-O-isopropylidene-D-<1-11C>-arabino-hex-1-enitol
  参考文献：
  名称：

  Oegren, M.; Langstroem, B., Journal of labelled compounds and radiopharmaceuticals, 1997, vol. 40, p. 798 - 800

  摘要：

  DOI：

文献信息

• Synthesis of D-[1-11C]Mannitol and its Enzymatic Oxidation to D-[1/6-11C]Fructose.
  作者：Mattias Ögren、Bengt Långström、Petros Mamos、Nikolaos Karamanos、Dionissios Papaioannou、George W. Francis、Teófilo Rojo

  DOI：10.3891/acta.chem.scand.52-1137

  日期：——

  D-[1-C-11]Mannitol was synthesised from [C-11]methyl iodide using a Wittig reaction in combination with an asymmetric dihydroxylation (AD) followed by acid hydrolysis of the protecting groups. Unreacted triphenylphosphine was quenched by the addition of an oxidant, N-methylmorpholine N-oxide, prior to the AD. In the synthesis of D-[1-C-11]fructose, tris(hydroxymethyl) aminomethane buffer was used as the solvent and D-mannitol dehydrogenase and nicotinamide adenine dinucleotide were added after pH adjustment. The enzyme was denatured and the solution was filtered prior to injection into a semi-preparative HPLC-system. Starting from 9.8 GBq [C-11]methyl iodide, the yield was 0.37 GBq D-[1-11C]mannitol and 0.12 GBq D-[1-C-11]fructose in 60 and 70 min, respectively. The radiochemical decay-corrected yield was 29% in the synthesis of D-[1-11C]mannitol and 15% for the synthesis of D-[1-C-11]fructose. The radiochemical purities exceeded 97% for the two C-11-labelled monosaccharides. A mixed C-11/C-13-experiment was performed in order to confirm the labelling positions with C-13 nuclear magnetic resonance spectroscopy.
• Oegren, M.; Langstroem, B., Journal of labelled compounds and radiopharmaceuticals, 1997, vol. 40, p. 801 - 806
  作者：Oegren, M.、Langstroem, B.

  DOI：——

  日期：——
• Oegren, M.; Langstroem, B., Journal of labelled compounds and radiopharmaceuticals, 1997, vol. 40, p. 798 - 800
  作者：Oegren, M.、Langstroem, B.

  DOI：——

  日期：——