Boc-Arg-His(biphenyl)-Arg-NHBzl | 1537176-88-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Arg-His(biphenyl)-Arg-NHBzl
• 英文别名: tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-[2-(4-phenylphenyl)-1H-imidazol-5-yl]propan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate
• CAS: 1537176-88-7
• 化学式: C₄₂H₅₆N₁₂O₅
• 分子量: 808.984
• InChiKey: PLWLELSPPDURGO-AFEGWXKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  59
• 可旋转键数：
  22
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  283
• 氢给体数：
  9
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Boc-Arg-His(biphenyl)-Arg-NHBzl 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以91%的产率得到Arg-His(biphenyl)-Arg-NHBzl
  参考文献：
  名称：

  Discovery of Short Peptides Exhibiting High Potency against Cryptococcus neoformans

  摘要：

  Rapid increase in the emergence of resistance against existing antifungal drugs created a need to discover new structural classes of antifungal agents. In this study we describe the synthesis of a new structural class of short antifungal peptidomimetcis, their activity, and plausible mechanism of action. The results of the study show that peptides lie and Ware more potent than the control drug amphotericin B, with no cytotoxicity to human cancer cells and noncancerous mammalian kidney cells. The selectivity of peptides to fungus is depicted by transmission electron microscopy studies, and it revealed that lie possibly disrupts the model membrane of the fungal pathogen.

  DOI：

  10.1021/ml500011v
• 作为产物：
  描述：

  N-α-trifluoroacetyl-L-histidine methyl ester 在 盐酸 、 N-羟基-7-氮杂苯并三氮唑 、 endo-N-Hydroxy-5-norbornene-2,3-dicarboximide 、 N,N-二异丙基乙胺 、 N,N'-二环己基碳二亚胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 三氟乙酸 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.27h， 生成 Boc-Arg-His(biphenyl)-Arg-NHBzl
  参考文献：
  名称：

  Discovery of Short Peptides Exhibiting High Potency against Cryptococcus neoformans

  摘要：

  Rapid increase in the emergence of resistance against existing antifungal drugs created a need to discover new structural classes of antifungal agents. In this study we describe the synthesis of a new structural class of short antifungal peptidomimetcis, their activity, and plausible mechanism of action. The results of the study show that peptides lie and Ware more potent than the control drug amphotericin B, with no cytotoxicity to human cancer cells and noncancerous mammalian kidney cells. The selectivity of peptides to fungus is depicted by transmission electron microscopy studies, and it revealed that lie possibly disrupts the model membrane of the fungal pathogen.

  DOI：

  10.1021/ml500011v

文献信息

• Discovery of Short Peptides Exhibiting High Potency against <i>Cryptococcus neoformans</i>
  作者：Amit Mahindra、Nitin Bagra、Nishima Wangoo、Shabana I. Khan、Melissa R. Jacob、Rahul Jain

  DOI：10.1021/ml500011v

  日期：2014.4.10

  Rapid increase in the emergence of resistance against existing antifungal drugs created a need to discover new structural classes of antifungal agents. In this study we describe the synthesis of a new structural class of short antifungal peptidomimetcis, their activity, and plausible mechanism of action. The results of the study show that peptides lie and Ware more potent than the control drug amphotericin B, with no cytotoxicity to human cancer cells and noncancerous mammalian kidney cells. The selectivity of peptides to fungus is depicted by transmission electron microscopy studies, and it revealed that lie possibly disrupts the model membrane of the fungal pathogen.