(E)-2(R)-(cyclopropylmethyl)-6-phenyl-4-hexenoic acid | 155295-64-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-2(R)-(cyclopropylmethyl)-6-phenyl-4-hexenoic acid
• 英文别名: (E)-(2R)-2-(cyclopropylmethyl)-6-phenyl-4-hexenoic acid；(E,2R)-2-(cyclopropylmethyl)-6-phenylhex-4-enoic acid
• CAS: 155295-64-0
• 化学式: C₁₆H₂₀O₂
• 分子量: 244.334
• InChiKey: ULGYHSCGDLMAHF-RGDDUWESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-2(R)-(cyclopropylmethyl)-6-phenyl-4-hexenoic acid 在 2,6-二甲基吡啶 、 lithium hydroxide 、 potassium carbonate 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 15.75h， 生成 (2R,4S,5R)-4,5-di(tert-butyldimethylsilyloxy)-2-(cyclopropylmethyl)-6-phenylhexanoic acid
  参考文献：
  名称：

  Novel small renin inhibitors containing 4,5- or 3,5-dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2P3 sites

  摘要：

  Renin inhibitors containing a 4,5- or a 3,5-dihydroxy-2-substituted-6-phenylhexanamide fragment at the P-2- P-3 Sites have been prepared and evaluated. The four possible diastereomeric diols of the two series of inhibitors were synthesized to determine the optimal configuration of the carbinol centers for these replacements. The most potent inhibitors of each series, 1a and 2c have a molecular weight of only 503 and IC50 values of 23 and 20 nM in a human plasma renin assay at pH 6.0. Their very low aqueous solubility limited their further evaluation. The efficacy of these P-2-P-3 replacements is a result of their ability to maintain the important hydrogen-bonds with the enzyme. Due to conformational differences with the dipeptide, adjustment at the P-2 Side chain was required. These 4,5- and 3,5-dihydroxyhexanamide segments could be seen as novel N-terminal dipeptide replacements. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)80011-4
• 作为产物：
  描述：

  1-苯基-3-丁烯-2-醇 在 lithium hydroxide 、 二溴亚砜 、 正丁基锂 、 1,5-已二烯 、 双氧水 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 、 水 、 1,2-二氯乙烷 为溶剂， 反应 24.25h， 生成 (E)-2(R)-(cyclopropylmethyl)-6-phenyl-4-hexenoic acid
  参考文献：
  名称：

  Novel small renin inhibitors containing 4,5- or 3,5-dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2P3 sites

  摘要：

  Renin inhibitors containing a 4,5- or a 3,5-dihydroxy-2-substituted-6-phenylhexanamide fragment at the P-2- P-3 Sites have been prepared and evaluated. The four possible diastereomeric diols of the two series of inhibitors were synthesized to determine the optimal configuration of the carbinol centers for these replacements. The most potent inhibitors of each series, 1a and 2c have a molecular weight of only 503 and IC50 values of 23 and 20 nM in a human plasma renin assay at pH 6.0. Their very low aqueous solubility limited their further evaluation. The efficacy of these P-2-P-3 replacements is a result of their ability to maintain the important hydrogen-bonds with the enzyme. Due to conformational differences with the dipeptide, adjustment at the P-2 Side chain was required. These 4,5- and 3,5-dihydroxyhexanamide segments could be seen as novel N-terminal dipeptide replacements. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)80011-4

文献信息

• US5354767A
  申请人：——

  公开号：US5354767A

  公开（公告）日：1994-10-11
• Novel small renin inhibitors containing 4,5- or 3,5-dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2P3 sites
  作者：Grace L. Jung、Paul C. Anderson、Murray Bailey、Monique Baillet、Gary W. Bantle、Sylvie Berthiaume、Pierre Lavallée、Montse Llinas-Brunet、Bounkham Thavonekham、Diane Thibeault、Bruno Simoneau

  DOI：10.1016/s0968-0896(98)80011-4

  日期：1998.12

  Renin inhibitors containing a 4,5- or a 3,5-dihydroxy-2-substituted-6-phenylhexanamide fragment at the P-2- P-3 Sites have been prepared and evaluated. The four possible diastereomeric diols of the two series of inhibitors were synthesized to determine the optimal configuration of the carbinol centers for these replacements. The most potent inhibitors of each series, 1a and 2c have a molecular weight of only 503 and IC50 values of 23 and 20 nM in a human plasma renin assay at pH 6.0. Their very low aqueous solubility limited their further evaluation. The efficacy of these P-2-P-3 replacements is a result of their ability to maintain the important hydrogen-bonds with the enzyme. Due to conformational differences with the dipeptide, adjustment at the P-2 Side chain was required. These 4,5- and 3,5-dihydroxyhexanamide segments could be seen as novel N-terminal dipeptide replacements. (C) 1998 Elsevier Science Ltd. All rights reserved.