N-methacryloyl-(L)-histidine methyl ester | 82822-09-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methacryloyl-(L)-histidine methyl ester
• 英文别名: methyl methacryloylhistidinate；L-methacrylamidohistidine methyl ester；MAH；methyl (2S)-3-(1H-imidazol-5-yl)-2-(2-methylprop-2-enoylamino)propanoate
• CAS: 82822-09-1
• 化学式: C₁₁H₁₅N₃O₃
• 分子量: 237.258
• InChiKey: LTELWGJDCBOKRL-VIFPVBQESA-N

物化性质

• 沸点：
  542.9±50.0 °C(Predicted)
• 密度：
  1.201±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  84.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  copper(II) nitrate trihydrate 、 N-methacryloyl-(L)-histidine methyl ester 以 水 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Valorisation of agricultural waste with an adsorption/nanofiltration hybrid process: from materials to sustainable process design

  摘要：

  使用印迹材料结合纳米过滤膜技术实现持续提取橄榄叶苷的过程，利用橄榄叶废料进行溶剂回收。

  DOI：

  10.1039/c7gc00912g
• 作为产物：
  描述：

  L-组氨酸 、 1-(1H-1,2,3-benzotriazol-1-yl)-2-methyl-2-propen-1-one 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 0.5h， 以90%的产率得到N-methacryloyl-(L)-histidine methyl ester
  参考文献：
  名称：

  Valorisation of agricultural waste with an adsorption/nanofiltration hybrid process: from materials to sustainable process design

  摘要：

  使用印迹材料结合纳米过滤膜技术实现持续提取橄榄叶苷的过程，利用橄榄叶废料进行溶剂回收。

  DOI：

  10.1039/c7gc00912g

文献信息

• AMINO ACID-BASED POLYMERIZABLE COMPOUNDS AND OPHTHALMIC DEVICES PREPARED THEREFROM
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20210388142A1

  公开（公告）日：2021-12-16

  Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I: wherein R, R 1 , and R 2 are as described herein.

  提供了基于氨基酸的可聚合化合物及其在眼科设备中的应用。该基于氨基酸的可聚合化合物的化学式为I：其中R，R1和R2如本文所述。
• Purification of urease from jack bean (<i>Canavalia ensiformis</i>) with copper (II) chelated poly(hydroxyethyl methacrylate-<i>N</i>-methacryloyl-(<scp>l</scp>)-histidine methyl ester) cryogels
  作者：Pınar Tekiner、Işık Perçin、Bahar Ergün、Handan Yavuz、Erol Aksöz

  DOI：10.1002/jmr.2204

  日期：2012.11

  Jack bean (Canavalia ensiformis) is the source of interesting proteins that contribute to modern biochemistry, and urease is the primary of these proteins. Owing to its role and occurrence in nature, urease has become a part of extensive studies. In this study, jack bean urease (JBU) was purified by immobilized metal affinity chromatography using Cu2+ chelated poly(hydroxyethyl methacrylate‐N‐meth

  蚕豆（Canavalia ensiformis）是有助于现代生物化学的有趣蛋白质的来源，脲酶是这些蛋白质的主要成分。由于其作用和在自然界中的发生，脲酶已成为广泛研究的一部分。在这项研究中，使用固定化的金属亲和色谱法，使用基于Cu 2+螯合的聚（甲基丙烯酸羟乙酯-N-甲基丙烯酰基- （l）-组氨酸甲酯）[PHEMAH-Cu 2+ ]的冷冻凝胶对杰克豆脲酶（JBU）进行纯化。合成了PHEMAH-Cu 2+冷冻凝胶，并对其溶胀度，形态（通过SEM），N-甲基丙烯酰-（l）-组氨酸甲酯和Cu 2+进行了表征掺入（通过元素分析和原子吸收分光光度法）。通过检查pH，流速和JBU浓度对结合的影响，优化了JBU与PHEMAH-Cu 2+冷冻凝胶的结合。JBU的最大结合量为23.2 mg /干克吸附剂。从豆粕中提取的JBU的最大结合量为67.8 mg /干克吸附剂。通过在20 mM磷酸盐缓冲液（pH 8.0）中的1
• The effects of a multifunctional oligomer and its incorporation strategies on the gene delivery efficiency of poly(l-lysine)
  作者：Dezhong Zhou、Congxin Li、Yuling Hu、Hao Zhou、Jiatong Chen、Zhengpu Zhang、Tianying Guo

  DOI：10.1039/c2cc31359f

  日期：——

  A novel multifunctional oligomer is synthesized and incorporated to enhance the gene delivery efficiency of PLL via non-electrostatic assembly and covalent grafting strategies. The improvement of the gene delivery efficiency is dependent on the gene carrying complex properties, and the properties are dependent on the oligomer incorporation strategy.

  通过非静电组装和共价接枝策略，合成并加入了一种新型多功能低聚物，以提高 PLL 的基因递送效率。基因递送效率的提高取决于基因携带复合物的特性，而这些特性又取决于低聚物的加入策略。
• PLL/pDNA/P(His-co-DMAEL) ternary complexes: assembly, stability and gene delivery
  作者：Dezhong Zhou、Congxin Li、Yuling Hu、Hao Zhou、Jiatong Chen、Zhengpu Zhang、Tianying Guo

  DOI：10.1039/c2jm30850a

  日期：——

  Poly(L-lysine) (PLL) is a kind of biocompatible and biodegradable polycation and can effectively condense plasmid DNA (pDNA) to form nano-scaled complexes. However, the ultra-low gene transfection efficiency limits its wide application in gene delivery. Here, an uncharged functional polymer P(His-co-DMAEL) is synthesized by reversible addition fragmentation transfer (RAFT) polymerization and characterized with 1H NMR spectrum and size exclusion chromatography (SEC). P(His-co-DMAEL) is assembled with pDNA and PLL to form PLL/pDNA/P(His-co-DMAEL) ternary complexes. Gel shift assays and dynamic light scattering (DLS) tests indicate that the stability of PLL/pDNA/P(His-co-DMAEL) ternary complexes under various conditions is much better than that of PLL/pDNA binary complexes. In vitro transfection shows that the gene transfection efficiency of PLL/pDNA/P(His-co-DMAEL) ternary complexes is much higher than that of PLL/pDNA counterparts and the “gold standard” of gene transfection, poly(ethyleneimine)/pDNA (PEI/pDNA) complexes, especially under serum conditions. Cytotoxicity assays show that PLL/pDNA/P(His-co-DMAEL) ternary complexes have no cytotoxicity. The ternary complexes have advanced the application of PLL as a gene carrier and will have enlightening significance for the development of novel gene and drug delivery carriers.

  聚(L-赖氨酸) (PLL) 是一种生物相容性、可生物降解的聚阳离子，可以有效凝聚质粒DNA (pDNA) 形成纳米级复合物。然而，超低的基因转染效率限制了其在基因递送中的广泛应用。在此，通过可逆加成断裂转移 (RAFT) 聚合合成了不带电荷的功能聚合物 P(His-co-DMAEL)，并通过 1 H NMR 谱和尺寸排阻色谱 (SEC) 进行了表征。 P(His-co-DMAEL)与pDNA和PLL组装形成PLL/pDNA/P(His-co-DMAEL)三元复合物。凝胶位移实验和动态光散射(DLS)测试表明PLL/pDNA/P(His-co-DMAEL)三元复合物在各种条件下的稳定性均明显优于PLL/pDNA二元复合物。体外转染结果表明，PLL/pDNA/P(His-co-DMAEL)三元复合物的基因转染效率远高于PLL/pDNA对应物，是基因转染的“金标准”聚(乙烯亚胺)/pDNA (PEI/pDNA) 复合物，尤其是在血清条件下。细胞毒性实验表明PLL/pDNA/P(His-co-DMAEL)三元复合物没有细胞毒性。该三元配合物推进了PLL作为基因载体的应用，对新型基因和药物递送载体的开发具有启发意义。
• Preparation of nanoparticles which contains histidine for immobilization of Trametes versicolor laccase
  作者：M. Emin Çorman、Nevra Öztürk、Nilay Bereli、Sinan Akgöl、Adil Denizli

  DOI：10.1016/j.molcatb.2009.12.017

  日期：2010.4