ethyl 2-(3-methoxyphenyl)imidazo[1,2-a]pyridine-8-carboxylate | 1033434-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-(3-methoxyphenyl)imidazo[1,2-a]pyridine-8-carboxylate
• 英文别名: Ethyl (2-(3-methoxyphenyl)imidazo[1,2-a]pyridin-8-yl)carboxylate
• CAS: 1033434-40-0
• 化学式: C₁₇H₁₆N₂O₃
• 分子量: 296.326
• InChiKey: IZOJVYPXPWFECW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-(3-methoxyphenyl)imidazo[1,2-a]pyridine-8-carboxylate 在 lithium aluminium tetrahydride 、 水 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 以83%的产率得到8-hydroxymethyl-2-(3-methoxyphenyl)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus

  摘要：

  A series of imidazo[1,2-a]pyrrolo[2,3-c]pyridines has been prepared and evaluated for their anti-BVDV activities in MDBK cells. From the synthesized analogues bearing modifications of the substituents at positions 2, 3, 7 and 8, compounds 10a, b, 16, 24, 25 and 26 exhibited significant anti-BVDV activities. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.01.023
• 作为产物：
  描述：

  2-氨基烟酸乙酯 、 2-溴-3‘-甲氧基苯乙酮 在 碳酸氢钠 作用下， 以 正丁醇 、 水 为溶剂， 反应 4.0h， 以43%的产率得到ethyl 2-(3-methoxyphenyl)imidazo[1,2-a]pyridine-8-carboxylate
  参考文献：
  名称：

  Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus

  摘要：

  A series of imidazo[1,2-a]pyrrolo[2,3-c]pyridines has been prepared and evaluated for their anti-BVDV activities in MDBK cells. From the synthesized analogues bearing modifications of the substituents at positions 2, 3, 7 and 8, compounds 10a, b, 16, 24, 25 and 26 exhibited significant anti-BVDV activities. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.01.023

文献信息

• Imidazo [1, 2-a] pyrrolo [3, 2-c] pyridine compounds useful as pestivirus inhibitors
  申请人：Neyts Johan

  公开号：US08404707B2

  公开（公告）日：2013-03-26

  The present invention relates to a series of novel imidazo[1,2-α]pyrrolo[3,2-c]pyridines (or also named 6H-1,3a,6-Tri-aza-αy-indacenes) and derivatives thereof, according to formula: (I); The present invention also relates to processes for the preparation of imidazo[1,2-α]pyrrolo[3,2-c]pyridines, their use as. a, medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Bovine Viral Diarrhea virus (BVDV).

  本发明涉及一系列新型咪唑[1,2-α]吡咯并[3,2-c]吡啶（或称为6H-1,3a,6-三氮杂-α-吲哚烷）及其衍生物，其化学式为：（I）；本发明还涉及制备咪唑[1,2-α]吡咯并[3,2-c]吡啶的方法，其用途包括作为药品，用于治疗或预防病毒感染以及用于制造治疗或预防病毒感染的药品，特别是用于感染属于黄病毒科的病毒，更具体地是用于感染牛病毒性腹泻病毒（BVDV）的病毒感染。
• IMIDAZO[1,2-A]PYRROLO[3,2-C]PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS
  申请人：Katholieke Universiteit Leuven

  公开号：EP2125807B1

  公开（公告）日：2011-08-03