2-(2,4-dichloro-5-fluorophenyl)quinoline-4-carboxylic acid | 903596-57-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(2,4-dichloro-5-fluorophenyl)quinoline-4-carboxylic acid
• 英文别名: 2-(2,4-dichloro-5-fluorophenyl)cinchoninic acid
• CAS: 903596-57-6
• 化学式: C₁₆H₈Cl₂FNO₂
• 分子量: 336.149
• InChiKey: VKEQSIOPIWQFHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2,4-dichloro-5-fluorophenyl)quinoline-4-carboxylic acid 、 4-氨基-5-异丙基-4H-1,2,4-三唑-3-硫醇 在 三氯氧磷 作用下， 反应 6.0h， 以70%的产率得到6-[2-(2,4-Dichloro-5-fluorophenyl)quinolin-4-yl]-3-propyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
  参考文献：
  名称：

  Holla, B. Shivarama; Poojary, K. Narayana; Poojary, Boja, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005, vol. 44, # 10, p. 2114 - 2119

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二氯-5-氟苯乙酮 、 靛红 在 sodium hydroxide 作用下， 生成 2-(2,4-dichloro-5-fluorophenyl)quinoline-4-carboxylic acid
  参考文献：
  名称：

  Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles

  摘要：

  A series of 2,4-dichloro-5-fluorophenyl containing 1,3,4-oxadiazoles (10 and 11) were synthesized by POCl3 cyclization of 2,4-dichloro-5-fluorobenzoyl hydrazide (4) and 2-(2,4-dichloro-5-fluorophenyl)cinchoninyl hydrazide (8) with aryloxyacetic acids (9). The structures of newly synthesized compounds were characterized by spectral and elemental analyses. All the compounds were screened for their antibacterial and antifungal activities. Compounds 10a, 10d and 11g showed very good antimicrobial activity. Compound 10d showed good bactericidal and fungicidal activities. (C) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.03.013