2,5-dibromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole | 1376707-80-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2,5-dibromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole
• 英文别名: 2,5-Dibromo-1-[2-bromo-6-(trifluoromethyl)phenyl]pyrrole；2,5-dibromo-1-[2-bromo-6-(trifluoromethyl)phenyl]pyrrole
• CAS: 1376707-80-0
• 化学式: C₁₁H₅Br₃F₃N
• 分子量: 447.875
• InChiKey: UKQHQAQXTRAECX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二氧化碳 、 2,5-dibromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole 在 正丁基锂 、 盐酸 作用下， 以 乙醚 、 正己烷 、 水 、 乙酸乙酯 为溶剂， 反应 0.25h， 以87%的产率得到2-bromo-1-[2-carboxy-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid
  参考文献：
  名称：

  Useful, regioflexible methods for functionalization of 1-phenylpyrrole derivatives

  摘要：

  Highly regioselective mono-, di- and tribrominations of 1-[2-(trifluoromethyl)phenyl]-1H-pyrrole and several derivatives were accomplished with N-bromosuccinimide under mild conditions. Combined applications of these brominations with organometallic (e.g., bromine/lithium exchange or metalation) reactions provided a novel regioflexible route to new multifunctionalised 1-phenylpyrrole derivatives. The structures of the new products were determined by spectroscopic methods and confirmed in three cases with single crystal X-ray diffraction measurements. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.070
• 作为产物：
  描述：

  邻氨基三氟甲苯 在 N-溴代丁二酰亚胺(NBS) 、 正丁基锂 、 potassium tert-butylate 、 对甲苯磺酸 作用下， 以 乙醚 、 正己烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 2.33h， 生成 2,5-dibromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole
  参考文献：
  名称：

  Useful, regioflexible methods for functionalization of 1-phenylpyrrole derivatives

  摘要：

  Highly regioselective mono-, di- and tribrominations of 1-[2-(trifluoromethyl)phenyl]-1H-pyrrole and several derivatives were accomplished with N-bromosuccinimide under mild conditions. Combined applications of these brominations with organometallic (e.g., bromine/lithium exchange or metalation) reactions provided a novel regioflexible route to new multifunctionalised 1-phenylpyrrole derivatives. The structures of the new products were determined by spectroscopic methods and confirmed in three cases with single crystal X-ray diffraction measurements. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.070

文献信息

• Useful, regioflexible methods for functionalization of 1-phenylpyrrole derivatives
  作者：Ferenc Faigl、Béla Mátravölgyi、Szilvia Deák、Tamás Holczbauer、Mátyás Czugler、László Balázs、István Hermecz

  DOI：10.1016/j.tet.2012.03.070

  日期：2012.6

  Highly regioselective mono-, di- and tribrominations of 1-[2-(trifluoromethyl)phenyl]-1H-pyrrole and several derivatives were accomplished with N-bromosuccinimide under mild conditions. Combined applications of these brominations with organometallic (e.g., bromine/lithium exchange or metalation) reactions provided a novel regioflexible route to new multifunctionalised 1-phenylpyrrole derivatives. The structures of the new products were determined by spectroscopic methods and confirmed in three cases with single crystal X-ray diffraction measurements. (C) 2012 Elsevier Ltd. All rights reserved.