(Z)-3-(2-bromo-4-methylphenylamino)-1-(4-chlorophenyl)-3-phenylprop-2-en-1-one | 1025784-70-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (Z)-3-(2-bromo-4-methylphenylamino)-1-(4-chlorophenyl)-3-phenylprop-2-en-1-one
• 英文别名: (Z)-3-(2-bromo-4-methylanilino)-1-(4-chlorophenyl)-3-phenylprop-2-en-1-one
• CAS: 1025784-70-6
• 化学式: C₂₂H₁₇BrClNO
• 分子量: 426.74
• InChiKey: RSMBGIQFEAISKW-STZFKDTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-4-甲基苯胺 、 p-chlorobenzoylphenylacetylene 反应 1.0h， 以98%的产率得到(Z)-3-(2-bromo-4-methylphenylamino)-1-(4-chlorophenyl)-3-phenylprop-2-en-1-one
  参考文献：
  名称：

  Simple and Efficient One‐Pot, Three‐Component, Solvent‐Free Synthesis of β‐Enaminones via Sonogashira Coupling–Michael Addition Sequences

  摘要：

  A simple, efficient, and environmentally friendly one-pot, three-component synthesis of beta-enaminones via Sonogashira coupling-Michael addition sequences under solvent-free conditions has been reported. Also the synthesis of beta-enaminones has been achieved in high yields by the direct reaction of amines with ynones under solvent-free conditions.

  DOI：

  10.1080/00397910801914343

文献信息

• Simple and Efficient One‐Pot, Three‐Component, Solvent‐Free Synthesis of β‐Enaminones via Sonogashira Coupling–Michael Addition Sequences
  作者：Sanjay S. Palimkar、Vijaykumar S. More、Kumar V. Srinivasan

  DOI：10.1080/00397910801914343

  日期：2008.4

  A simple, efficient, and environmentally friendly one-pot, three-component synthesis of beta-enaminones via Sonogashira coupling-Michael addition sequences under solvent-free conditions has been reported. Also the synthesis of beta-enaminones has been achieved in high yields by the direct reaction of amines with ynones under solvent-free conditions.