4-isopropoxycarbonyl quinoline | 142729-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-isopropoxycarbonyl quinoline
• 英文别名: Propan-2-yl quinoline-4-carboxylate
• CAS: 142729-97-3
• 化学式: C₁₃H₁₃NO₂
• mdl: MFCD23146218
• 分子量: 215.252
• InChiKey: AXYMXFYOUGUQFJ-UHFFFAOYSA-N

物化性质

• 沸点：
  325.0±15.0 °C(Predicted)
• 密度：
  1.144±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  喹啉 、 草酸单异丙酯 在 sodium persulfate 、 硫酸 、 silver nitrate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 以39%的产率得到isopropyl quinoline-2-carboxylate
  参考文献：
  名称：

  一种新颖、简单且廉价的醇类烷基自由基来源，可用于杂芳烃取代

  摘要：

  通过 S2O8= 银催化的草酸单酯脱羧反应，可以很容易地从仲醇或叔醇以廉价和简单的方式制备烷基自由基。它们被用于两相系统中杂芳烃碱的烷基化，具有高产率和选择性。

  DOI：

  10.1246/cl.1992.1295

文献信息

• A novel convenient and selective alkoxycarbonylation of heteroaromatic bases by oxalic acid monoesters
  作者：Fausta Coppa、Francesca Fontana、Edoardo Lazzarini、Francesco Minisci、Giuseppe Pianese、Lihua Zhao

  DOI：10.1016/s0040-4039(00)79599-2

  日期：1992.5

  ethoxycarbonyl radicals were easily produced by silver-catalyzed decarboxylation of methyl and ethyl esters of oxalic acid by S2O8=. They were utilized for the alkoxycarbonylation of heteroaromatic bases with high yield and selectivity in a two-phase system, suitable for practical applications.

  甲氧基和乙氧基羰基很容易通过S 2 O 8 =通过银催化草酸的甲酯和乙酯的羧化反应制得。它们被用于两相体系中的高收率和选择性的杂芳族碱的烷氧基羰基化反应，适合实际应用。
• RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, AND NEW COMPOUND
  申请人：Utsumi Yoshiyuki

  公开号：US20120148955A1

  公开（公告）日：2012-06-14

  A resist composition including: a base component (A) which exhibits changed solubility in a developing solution under action of acid; a nitrogen-containing organic compound component (C) containing a compound (C1) represented by general formula (c1) shown below; and an acid generator component (B) which generates acid upon exposure, provided that the compound (C1) is excluded from the acid generator component (B): wherein R N represents a nitrogen-containing heterocyclic group which may have a substituent; X 0 represents a linear or branched divalent aliphatic hydrocarbon group of 1 to 10 carbon atoms, a cyclic divalent aliphatic hydrocarbon group of 3 to 20 carbon atoms or a divalent aliphatic hydrocarbon group of 3 to 20 carbon having a cyclic partial structure, or any one of these groups in which some or all of the hydrogen atoms thereof have been substituted with fluorine atoms; and M + represents an organic cation.
• US8846291B2
  申请人：——

  公开号：US8846291B2

  公开（公告）日：2014-09-30
• [EN] MODULATION OF NUCLEAR RECEPTORS ACTIVITY<br/>[FR] MODULATION DE L'ACTIVITE DES RECEPTEURS NUCLEAIRES
  申请人：CAREX S A

  公开号：WO2004072046A2

  公开（公告）日：2004-08-26

  The present invention relates to specific compounds and pharmaceutically acceptable salts thereof; methods for synthesizing these compounds; compositions comprising at least one of these compounds or a pharmaceutically acceptable salt thereof; and methods for modulating liver-X receptors (LXRs) activity. The present invention further concerns methods for treating and/or preventing a disease or disorder selected from the group consisting of dyslipidemia, including hyperlipidemia, dyslipoproteinemia, including hyperlipoproteinemia, disorders related to cholesterol or bile acid metabolisms, including hypercholesterolemia, gall stone or gall bladder disorders, cardiovascular disease, including atherosclerotic cardiovascular diseases, coronary artery diseases, peripheral vascular diseases, cerebrovascular diseases, thrombotic disorders, restenosis or septic shock, CNS diseases including those affecting cognitive function or age related disorders such as Alzheimer’s disease, Syndrome X, a liver-X receptor-associated disorder, obesity, pancreatitis, hypertension, renal disease, cancer, rheumatoid arthritis, inflammation, skin proliferative disorders, including psoriasis, atopic dermatitis or acne, and sexual impotence, comprising administering a therapeutically effective amount of a composition comprising at least one compound or a pharmaceutically acceptable salt thereof of the invention.
• A Novel, Simple and Cheap Source of Alkyl Radicals from Alcohols, Useful for Heteroaromatic Substitution
  作者：Fausta Coppa、Francesca Fontana、Edoardo Lazzarini、Francesco Minisci、Giuseppe Pianese、Lihua Zhao

  DOI：10.1246/cl.1992.1295

  日期：1992.7

  Alkyl radicals were easily produced from secondary or tertiary alcohols in a cheap and simple way by silver-catalyzed decarboxylation of oxalic acid monoesters by S2O8=. They were utilized for the alkylation of heteroaromatic bases in a two-phase system, with high yields and selectivity.

  通过 S2O8= 银催化的草酸单酯脱羧反应，可以很容易地从仲醇或叔醇以廉价和简单的方式制备烷基自由基。它们被用于两相系统中杂芳烃碱的烷基化，具有高产率和选择性。