2-((1-methylcyclohexyl)oxy)ethanol | 6193-73-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-((1-methylcyclohexyl)oxy)ethanol
• 英文别名: 2-<1-Methylcyclohexyloxy>aethanol；2-(1-Methylcyclohexyloxy)aethanol；2-(1-Methylcyclohexyl)oxyethanol
• CAS: 6193-73-3
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: BHLHMTPOOATSFN-UHFFFAOYSA-N

物化性质

• 沸点：
  107.5-108.0 °C(Press: 17 Torr)
• 密度：
  0.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-甲基环己醇 、 2-氯乙醇 在 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 0.25h， 以75%的产率得到2-((1-methylcyclohexyl)oxy)ethanol
  参考文献：
  名称：

  Microwave Mediated Protection of Hindered Phenols and Alcohols

  摘要：

  在微波照射下，使用不同的烷基化试剂，在KOH/DMSO的存在下，将 hindered 酚和醇保护为其相应的醚。$$R-OH\;{KOH/DMSO,\;R^{\prime}-X,\;MW \\{\vec{10-15\;Mins,\;80%-90%\;Yield}}}\;R^{{/}^O{\backslash}}R^{\prime}$$.

  DOI：

  10.5012/jkcs.2012.56.6.706

文献信息

• Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto
  申请人：Suwa Yorimasa

  公开号：US20070093536A1

  公开（公告）日：2007-04-26

  The present invention is intended to elucidate a molecular target of an antidiabetic such as a thiazolidine derivative. The present invention provides a screening method for an antidiabetic, comprising the steps of: bringing a candidate substance to be screened into contact with a protein represented by the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 with the deletion, substitution, addition, or insertion of one or plural amino acids and interacting with the antidiabetic; and detecting the interaction between the candidate substance and the protein.