(Z)-3-(2-methoxyphenyl)prop-2-enamide | 118653-15-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (Z)-3-(2-methoxyphenyl)prop-2-enamide
• 英文别名: (Z)-3-(2-methoxyphenyl)acrylamide；(Z)-2-methoxycinnamamide；2-methoxy-cis-cinnamic acid amide；2-Methoxy-cis-zimtsaeure-amid
• CAS: 118653-15-9
• 化学式: C₁₀H₁₁NO₂
• 分子量: 177.203
• InChiKey: LEKDUITWBBCUQY-SREVYHEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ethoxycarbonyl (Z)-3-(2-methoxyphenyl)prop-2-enoate 在 氨 作用下， 以 乙醚 为溶剂， 以68%的产率得到(Z)-3-(2-methoxyphenyl)prop-2-enamide
  参考文献：
  名称：

  Brettle, Roger; Mosedale, Alan J., Journal of the Chemical Society. Perkin transactions I, 1988, p. 2185 - 2196

  摘要：

  DOI：

文献信息

• Photocatalyst-free visible light promoted <i>E</i> → <i>Z</i> isomerization of alkenes
  作者：Jianbin Xu、Na Liu、Haiping Lv、Chixian He、Zining Liu、Xianfu Shen、Feixiang Cheng、Baomin Fan

  DOI：10.1039/c9gc04303a

  日期：——

  A simple and green method of visible light driven photocatalytic E to Z isomerization of alkenes has been developed. A variety of (Z)-alkenes can be prepared in the presence of visible light, without any additional photocatalyst. This protocol features photocatalyst-free conditions, which are mild, tolerant, and operationally simple, and is easy to implement.

  一个简单而驱动光催化可见光的绿色方法Ë到ž烯烃异构化已经研制成功。可以在可见光存在下制备各种（Z）烯烃，而无需任何其他光催化剂。该协议具有无光催化剂的条件，该条件温和，宽容且操作简单，易于实施。
• Zinc-Mediated Facile Synthesis of α,β-Unsaturated Primary Amides
  作者：Sunlin Feng、Zhiying Zhang、Shilei Jiang、Xiaochun Yu

  DOI：10.3184/030823410x520741

  日期：2010.7

  A general method for the synthesis of α,β-unsaturated primary amides was achieved by an one-pot, triphenylphosphine- and zinc powder-promoted Wittig reaction of bromoacetamide and aldehydes under solvent-free conditions.

  合成α,β-不饱和伯酰胺的一般方法是通过溴乙酰胺和醛在无溶剂条件下的一锅、三苯基膦和锌粉促进的Wittig反应实现的。
• Proteasome inhibitors and methods of using the same
  申请人：Bernadini Raffaella

  公开号：US20050107307A1

  公开（公告）日：2005-05-19

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以通过抑制蛋白酶体活性等方式调节细胞凋亡。这些化合物和组合物可以用于诱导细胞凋亡并治疗癌症等疾病，以及与蛋白酶体活性直接或间接相关的其他疾病。
• PROTEASOME INHIBITORS AND METHODS OF USING THE SAME
  申请人：Bernardini Raffaella

  公开号：US20090291918A1

  公开（公告）日：2009-11-26

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节细胞凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可以用于诱导细胞凋亡和治疗癌症及其他与蛋白酶体活性直接或间接相关的疾病。
• Proteasome Inhibitors and Methods of Using the Same
  申请人：Bernardini Raffaella

  公开号：US20110144033A1

  公开（公告）日：2011-06-16

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节细胞凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可用于诱导细胞凋亡和治疗癌症和其他与蛋白酶体活性直接或间接相关的疾病的方法。