8-acetyl-3-methoxy-benzo[c]chromen-6-one | 448218-66-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 8-acetyl-3-methoxy-benzo[c]chromen-6-one
• 英文别名: 8-acetyl-3-methoxybenzo[c]chromen-6-one
• CAS: 448218-66-4
• 化学式: C₁₆H₁₂O₄
• 分子量: 268.269
• InChiKey: FWTOKBXCPIENSR-UHFFFAOYSA-N

物化性质

• 沸点：
  480.5±38.0 °C(Predicted)
• 密度：
  1.282±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-acetyl-3-methoxy-benzo[c]chromen-6-one 在 对甲苯磺酸 作用下， 以 乙二醇 、 苯 为溶剂， 以3.6 g (60%)的产率得到3-methoxy-8-(2-methyl-[1,3]-dioxolane-2-yl)-benzo[c]chromen-6-one
  参考文献：
  名称：

  Non-steroidal estrogen receptor ligands

  摘要：

  揭示了一种新型非甾体雌激素受体配体及其合成方法。这些新型分子旨在用于治疗雌激素受体相关疾病状态的治疗制剂。指定的化合物是四环衍生物，已被证明对人类雌激素依赖性癌细胞具有抗增殖作用，并具有良好的结合亲和力与雌激素受体。

  公开号：

  US20020156077A1
• 作为产物：
  描述：

  5-乙酰水杨酸甲酯 在 吡啶 、 氢氧化钾 、 四(三苯基膦)钯 、 氯化亚砜 、 potassium carbonate 作用下， 以 乙二醇二甲醚 、 乙醇 、 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 7.0h， 生成 8-acetyl-3-methoxy-benzo[c]chromen-6-one
  参考文献：
  名称：

  Synthesis and Evaluation of a Novel Nonsteroidal-Specific Endothelial Cell Proliferation Inhibitor

  摘要：

  The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substituted dibenzo[b,d]pyran-6-one scaffold, exemplified by structures 9a and 10, and report preliminary in vitro activity data indicating that this scaffold is a promising lead for the development of specific inhibitors of endothelial cell proliferation.

  DOI：

  10.1021/jm034007d

文献信息

• Non-steroidal estrogen receptor ligands
  申请人：——

  公开号：US20020156077A1

  公开（公告）日：2002-10-24

  Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyclic derivatives and have been shown to be antiproliferative against human estrogen-dependent cancer cells and to have good binding affinity for the estrogen receptor.

  揭示了一种新型非甾体雌激素受体配体及其合成方法。这些新型分子旨在用于治疗雌激素受体相关疾病状态的治疗制剂。指定的化合物是四环衍生物，已被证明对人类雌激素依赖性癌细胞具有抗增殖作用，并具有良好的结合亲和力与雌激素受体。
• Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
  申请人：Sherris David

  公开号：US20060257337A1

  公开（公告）日：2006-11-16

  Described herein are compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photodamaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin, involving aberrant angiogenesis and hyperplasia employing one or more benzo[c]chromen-6-one derivatives.

  本文描述了一种预防和/或治疗皮肤疾病的组合物和方法，包括但不限于银屑病和特应性皮炎，以及提供抗衰老益处，减少皱纹和老化皮肤的出现，改善皮肤颜色，治疗光损伤皮肤，改善皮肤的光泽和清晰度以及完美度，以及使皮肤呈现整体健康和年轻外观，涉及使用一个或多个苯并[c]色素-6-酮衍生物的异常血管生成和增生。
• Dibenzo[c]chromen-6-one derivatives as anti-cancer agents
  申请人：Nanodesign Inc.

  公开号：US06632835B2

  公开（公告）日：2003-10-14

  Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines and endothelial cells and methods of synthesis are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of cancer through either anti-angiogenesis or other anti-cancer mechanisms. The compounds specified are 6H-dibenzo[b,d]pyran-6-one derivatives and have been shown to be antiproliferative against human endothelial cells.

  本文披露了对上皮癌细胞系和内皮细胞表现出抗增殖效应的分子以及其合成方法。这些分子旨在用于治疗癌症的治疗制剂中，通过抗血管生成或其他抗癌机制来治疗癌症。指定的化合物是6H-二苯并[b,d]吡喃-6-酮衍生物，并已显示对人类内皮细胞具有抗增殖作用。
• COMPOSITIONS AND METHODS TO TREAT DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS
  申请人：Sherris I. David

  公开号：US20070197567A1

  公开（公告）日：2007-08-23

  Described herein are compositions and methods for preventing and/or treating diseases involving aberrant angiogenesis employing one or more benzo[c]chromen-6-one derivatives.

  本文描述了使用一种或多种苯并[c]色酮-6-酮衍生物预防和/或治疗涉及异常血管生成的疾病的组合物和方法。
• COMPOSITIONS AND METHODS TO TREAT SKIN DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS
  申请人：SHERRIS David

  公开号：US20110268679A1

  公开（公告）日：2011-11-03

  Described herein are compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photodamaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin, involving aberrant angiogenesis and hyperplasia employing one or more benzo[c]chromen-6-one derivatives.

  本文描述了一种预防和/或治疗皮肤疾病的组合物和方法，包括但不限于银屑病和特应性皮炎，以及提供抗衰老效益，从而减少皱纹和老化皮肤的出现，改善皮肤颜色，治疗光损伤皮肤，改善皮肤的光泽度和清晰度，以及整体健康和年轻的外观，涉及异常血管生成和增生，并采用一种或多种苯并[c]色酮衍生物。