1-Methoxy-4-[3-(4-methoxybut-2-ynoxy)propoxy]but-2-yne | 1008516-59-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methoxy-4-[3-(4-methoxybut-2-ynoxy)propoxy]but-2-yne
• 英文别名: 1-methoxy-4-[3-(4-methoxybut-2-ynoxy)propoxy]but-2-yne
• CAS: 1008516-59-3
• 化学式: C₁₃H₂₀O₄
• 分子量: 240.299
• InChiKey: ZVBHKXANXFHHMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Methoxy-4-[3-(4-methoxybut-2-ynoxy)propoxy]but-2-yne 、 丁炔二酸二叔丁酯 乙炔二羧酸二叔丁酯 在 bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 氢气 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以12%的产率得到di-tert-butyl 8,11-bis(methoxymethyl)-1,4,5,7-tetrahydro-3H-benzo[g][1,5]dioxonine-9,10-dicarboxylate
  参考文献：
  名称：

  Enantioselective synthesis of planar-chiral metacyclophanes through cationic Rh(I)/modified-BINAP-catalyzed inter- and intramolecular alkyne cyclotrimerizations

  摘要：

  We have achieved the first catalytic enantioselective synthesis of planar-chiral metacyclophanes by means of cationic Rh(I)/(S)-xyl-H-8-BINAP or (R)-H-8-BINAP complex-catalyzed inter- and intramolecular alkyne cyclotrimerizations. This highly enantioselective catalysis represents a versatile new method for the preparation of planar-chiral metacyclophanes. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.10.085
• 作为产物：
  描述：

  溴甲基甲基醚 、 3-(3-(prop-2-ynyloxy)propoxy)propyne 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 生成 1-Methoxy-4-[3-(4-methoxybut-2-ynoxy)propoxy]but-2-yne
  参考文献：
  名称：

  Enantioselective synthesis of planar-chiral metacyclophanes through cationic Rh(I)/modified-BINAP-catalyzed inter- and intramolecular alkyne cyclotrimerizations

  摘要：

  We have achieved the first catalytic enantioselective synthesis of planar-chiral metacyclophanes by means of cationic Rh(I)/(S)-xyl-H-8-BINAP or (R)-H-8-BINAP complex-catalyzed inter- and intramolecular alkyne cyclotrimerizations. This highly enantioselective catalysis represents a versatile new method for the preparation of planar-chiral metacyclophanes. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.10.085

文献信息

• Enantioselective synthesis of planar-chiral metacyclophanes through cationic Rh(I)/modified-BINAP-catalyzed inter- and intramolecular alkyne cyclotrimerizations
  作者：Ken Tanaka、Hiromi Sagae、Kazuki Toyoda、Masao Hirano

  DOI：10.1016/j.tet.2007.10.085

  日期：2008.1

  We have achieved the first catalytic enantioselective synthesis of planar-chiral metacyclophanes by means of cationic Rh(I)/(S)-xyl-H-8-BINAP or (R)-H-8-BINAP complex-catalyzed inter- and intramolecular alkyne cyclotrimerizations. This highly enantioselective catalysis represents a versatile new method for the preparation of planar-chiral metacyclophanes. (c) 2007 Elsevier Ltd. All rights reserved.