Highly Efficient and Regioselective Platinum(II)-Catalyzed Tandem Synthesis of Multiply Substituted Indolines and Tetrahydroquinolines
作者:Xin-Yuan Liu、Chi-Ming Che
DOI:10.1002/anie.200805383
日期:2009.3.16
special advantage: The platinum(II)‐catalyzed tandemcyclization of aminoalkynes with 1,3‐diketones offers a new and highly efficient method for the synthesis of indolines and tetrahydroquinolines (see scheme; M.S.=molecular sieves). This transformation affords good to excellent product yields with high regio‐ and chemoselectivity under mild reactionconditions.
一个特殊的优势:带有1,3-二酮的铂(Ⅱ)催化的氨基炔的串联环化为合成二氢吲哚和四氢喹啉提供了一种高效的新方法(见方案; MS =分子筛)。在温和的反应条件下,这种转化可提供良好的产品收率,具有很高的区域选择性和化学选择性。
Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles
作者:Wenzheng Zhang、Guangyang Xu、Lin Qiu、Jiangtao Sun
DOI:10.1039/c8ob00826d
日期:——
novel protocol for the synthesis of C5-alkylated indole derivatives via a gold-catalyzed reaction of indolines with diazo compounds and subsequent oxidative aromatization has been developed. C–H bond functionalization selectively occurs at the C5-position of indolines without a directing group. The experimental operation is simple and the whole process can be manipulated in one-pot.