Methyl(methylamino)alumanylium;chloride | 84738-96-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 金属烷基卤化物
• 英文名称: Methyl(methylamino)alumanylium;chloride
• 英文别名: methyl(methylamino)alumanylium;chloride
• CAS: 84738-96-5
• 化学式: C₂H₇AlClN
• 分子量: 107.519
• InChiKey: XOSRPQMHPNJURV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.56
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯甲酸甲酯 、 Methyl(methylamino)alumanylium;chloride 以 苯 为溶剂， 反应 12.0h， 以91%的产率得到N-甲基苯甲酰胺
  参考文献：
  名称：

  Levin, Jeremy I.; Turos, Edward; Weinreb, Steven M., Synthetic Communications, 1982, vol. 12, # 13, p. 989 - 994

  摘要：

  DOI：
• 作为产物：
  描述：

  三甲基铝 生成 Methyl(methylamino)alumanylium;chloride
  参考文献：
  名称：

  GARIGIPATI, RAVI S., TETRAHEDRON LETT., 31,(1990) N4, C. 1969-1972

  摘要：

  DOI：

文献信息

• An efficient conversion of nitriles to amidines
  作者：Ravi S. Garigipati

  DOI：10.1016/s0040-4039(00)88891-7

  日期：1990.1

  A convenient method has been developed for direct conversion of nitriles to amidines in high yields. The method can also be applied to the preparation of guanidines from N-alkyl cyanamides.

  已经开发了一种方便的方法，用于以高收率将腈直接转化为am。该方法还可用于由N-烷基氰酰胺制备胍。
• Synthesis of LY503430 by using a selective rearrangement of β-amino alcohols induced by DAST
  作者：Béranger Duthion、Domingo Gomez Pardo、Janine Cossy

  DOI：10.3998/ark.5550190.p008.252

  日期：——

  LY503430, an optically active β-fluoroamine, is a potential therapeutic agent for the Parkinson's disease. Different strategies have been studied to synthesize this molecule using a regioselective and stereospecific rearrangement of β-amino alcohols into β-fluoroamines induced by DAST. This reaction allowed the synthesis of LY503430 with an excellent enantiomeric excess.

  LY503430 是一种光学活性 β-氟胺，是帕金森病的潜在治疗剂。已经研究了使用 DAST 诱导的 β-氨基醇区域选择性和立体特异性重排成 β-氟胺的不同策略来合成该分子。该反应允许合成具有极好对映体过量的 LY503430。
• Synthesis of Pluriaminated Pyridines
  作者：Angela De Munno、Vincenzo Bertini、Nevio Picci、Francesca Iemma、Marco Pocci

  DOI：10.3987/com-98-8144

  日期：——

  The key reagent 3,5-dichloro-4-pyridinecarbonitrile (1) was used to synthesize 4-aminomethylpyridine derivatives 3,5-disubstituted with various amino groups, very active as inhibitors of diamine oxidase. The study of the reaction allowed to discover conditions for the gradual substitution in good yields of the two chlorine atoms to give symmetrically and unsymmetrically disubstituted derivatives (3), or the substitution of the cyano group, or the formation of amidines. The reduction of the cyano to aminomethyl group in compounds (3) afforded the target bioactive products.
• Towards the Synthesis of Calyculin: A Synthetic Intermediate Corresponding to the C(26)-C(37) Fragment
  作者：Henry A. Vaccaro、Daniel E. Levy、Akiyoshi Sawabe、Thomas Jaetsch、Satoru Masamune

  DOI：10.1016/0040-4039(92)88107-g

  日期：1992.4

  The synthetic intermediate 2 corresponding to the C(26)-C(37) fragment of calyculin A (1) has been synthesized. Key transformations include the efficient one-pot construction of the oxazole system embedded in 1 without epimerization-alpha [C(30)] to the ring, and the in situ formation of the dimethylamine by opening an N-methyllactam with Meerwein's reagent and trapping the resultant methylamine with formaldehyde.