(1R,20S,25R)-8,13,26-trioxa-21-azapentacyclo[18.6.0.02,7.014,19.021,25]hexacosa-2,4,6,14,16,18-hexaene | 1200433-05-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1R,20S,25R)-8,13,26-trioxa-21-azapentacyclo[18.6.0.02,7.014,19.021,25]hexacosa-2,4,6,14,16,18-hexaene
• CAS: 1200433-05-1
• 化学式: C₂₂H₂₅NO₃
• 分子量: 351.445
• InChiKey: ZJAQEPMOBWAEMQ-BHIFYINESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2-(1,4-丁烷二基二氧基)双苯甲醛 、 L-脯氨酸 以 乙腈 为溶剂， 以88%的产率得到(1R,20S,25R)-8,13,26-trioxa-21-azapentacyclo[18.6.0.02,7.014,19.021,25]hexacosa-2,4,6,14,16,18-hexaene
  参考文献：
  名称：

  Stereoselective synthesis of oxazolidine, hexahydropyrrolo [2,1-b] oxazole, and tetrahydro-2H-oxazolo [3,2-c] thiazole grafted macrocycles through intramolecular 1,3-dipolar cycloaddition reaction

  摘要：

  A facile one-pot synthesis of oxazolidine, hexahydropyrrolooxazole and tetrahydro-2H-oxazolothiazole grafted macrocycles through intramolecular 1,3-dipolar cycloaddition reaction (1,3-DC reaction) is reported. X-ray diffraction studies and 2D NOESY experiments of the cycloadducts proved the stereo- and regiochemistry of the cycloaddition. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.122

文献信息

• Stereoselective synthesis of oxazolidine, hexahydropyrrolo [2,1-b] oxazole, and tetrahydro-2H-oxazolo [3,2-c] thiazole grafted macrocycles through intramolecular 1,3-dipolar cycloaddition reaction
  作者：S. Purushothaman、R. Raghunathan

  DOI：10.1016/j.tetlet.2009.09.122

  日期：2009.12

  A facile one-pot synthesis of oxazolidine, hexahydropyrrolooxazole and tetrahydro-2H-oxazolothiazole grafted macrocycles through intramolecular 1,3-dipolar cycloaddition reaction (1,3-DC reaction) is reported. X-ray diffraction studies and 2D NOESY experiments of the cycloadducts proved the stereo- and regiochemistry of the cycloaddition. (C) 2009 Elsevier Ltd. All rights reserved.