3-(4-甲硫基苯基)-3-氧代丙酸乙酯 | 63131-31-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-(4-甲硫基苯基)-3-氧代丙酸乙酯
• 英文名称: ethyl 3-(4-methylthiophenyl)-3-oxopropionate
• 英文别名: ethyl 3-(4-methylthiophenyl)-3-oxopropanoate；4-Methylthio-benzoylessigsaeureaethylester；Ethyl 3-(4-(methylthio)phenyl)-3-oxopropanoate；ethyl 3-(4-methylsulfanylphenyl)-3-oxopropanoate
• CAS: 63131-31-7
• 化学式: C₁₂H₁₄O₃S
• 分子量: 238.307
• InChiKey: QOZARDBBEJXHBJ-UHFFFAOYSA-N

物化性质

• 沸点：
  352.5±22.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-甲硫基苯基)-3-氧代丙酸乙酯 在 正丁基锂 、 盐酸羟胺 、 三氯氧磷 作用下， 以 乙醚 、 乙醇 为溶剂， 生成 (3-Azepan-1-yl-propyl)-benzo[1,3]dioxol-5-ylmethyl-[3-(4-methylsulfanyl-phenyl)-isoxazol-5-yl]-amine
  参考文献：
  名称：

  Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)

  摘要：

  The synthesis and biological evaluation of a series of nonpeptidic small molecule antagonists of the human platelet thrombin receptor (PAR-1) are described. Optimization of the 5-amino-3-arylisoxazole lead resulted in an approximate 100-fold increase in potency. The most potent of these compounds (54) inhibits platelet activation with IC50S of 90 nM against the thrombin receptor agonist peptide (TRAP) and 510 nM against thrombin as the agonist. Further, antagonist 54 fully blocks platelet aggregation stimulated by 1 nM thrombin for 10 min. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(01)00745-4
• 作为产物：
  描述：

  4-甲硫基苯乙酮 、 碳酸二乙酯 以 水 为溶剂， 生成 3-(4-甲硫基苯基)-3-氧代丙酸乙酯
  参考文献：
  名称：

  EP1340749

  摘要：

  公开号：

文献信息

• Inhibitors of glycogen synthase kinase 3
  申请人：——

  公开号：US20020156087A1

  公开（公告）日：2002-10-24

  New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

  提供新的基于嘧啶或吡啶的化合物、组合物以及抑制糖原合酶激酶（GSK3）活性的方法和治疗GSK3介导的体内疾病的方法。发明的方法、化合物和组合物可以单独使用，或者与其他药理活性物质结合使用，在治疗由GSK3活性介导的疾病中，如糖尿病、阿尔茨海默病和其他神经退行性疾病、肥胖、动脉粥样硬化性心血管疾病、原发性高血压、多囊卵巢综合征、X综合征、缺血、创伤性脑损伤、双相情感障碍、免疫缺陷或癌症。
• Antimalarial Pyrido[1,2-<i>a</i>]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model
  作者：Kawaljit Singh、John Okombo、Christel Brunschwig、Ferdinand Ndubi、Linley Barnard、Chad Wilkinson、Peter M. Njogu、Mathew Njoroge、Lizahn Laing、Marta Machado、Miguel Prudêncio、Janette Reader、Mariette Botha、Sindisiwe Nondaba、Lyn-Marie Birkholtz、Sonja Lauterbach、Alisje Churchyard、Theresa L. Coetzer、Jeremy N. Burrows、Clive Yeates、Paolo Denti、Lubbe Wiesner、Timothy J. Egan、Sergio Wittlin、Kelly Chibale

  DOI：10.1021/acs.jmedchem.6b01641

  日期：2017.2.23

  Further structure–activity relationship (SAR) studies on the recently identified pyrido[1,2-a]benzimidazole (PBI) antimalarials have led to the identification of potent, metabolically stable compounds with improved in vivo oral efficacy in the P. berghei mouse model and additional activity against parasite liver and gametocyte stages, making them potential candidates for preclinical development. Inhibition

  对最近鉴定出的吡啶并[1,2- a ]苯并咪唑（PBI）抗疟药的进一步结构-活性关系（SAR）研究已导致鉴定出有效的，代谢稳定的化合物，从而在伯氏疟原虫小鼠模型中具有改善的体内口服功效以及针对寄生虫肝脏和配子细胞阶段的额外活性，使其成为临床前开发的潜在候选者。抑制hezozoin的形成可能有助于其作用机理。
• [EN] INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3<br/>[FR] INHIBITEURS DE GLYCOGENE SYNTHASE KINASE 3
  申请人：CHIRON CORPORATION

  公开号：WO1999065897A1

  公开（公告）日：1999-12-23

  (EN) New pyrimidine or pyridine based compounds, having the structure (I), compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) $i(in vitro) and of treatment of GSK3 mediated disorders $i(in vivo) are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder immunodeficiency or cancer.(FR) L'invention concerne de nouveaux composés à base de pyrimidine ou de pyridine de la structure (I), des compositions et méthodes d'inhibition de l'activité de glycogène synthase kinase (GSK3) $i(in vitro) et de traitement de troubles induits par GSK3 $i(in vivo). Les méthodes, composés et compositions de la présente invention peuvent s'utiliser seuls ou en combinaison avec d'autres agents actifs du point de vue pharmacologique pour le traitement de troubles induits par l'activité de GSK3, tels que le diabète, la maladie d'Alzheimer et d'autres troubles neurodégénératifs, l'obésité, une maladie cardiovasculaire athéroscléreuse, l'hypertension artérielle essentielle, le syndrome des ovaires polkykystiques, le syndrome X, l'ischémie, le traumatisme cérébral, un trouble bipolaire, l'immunodéficience ou le cancer.

  新的以嘧啶或吡啶为基础的化合物，具有结构（I），提供了抑制糖原合成酶激酶（GSK3）$i（in vitro）活性和治疗GSK3介导的疾病$i（in vivo）的组合物和方法。本发明的方法、化合物和组合物可以单独使用，也可以与其他药理活性剂联合使用，用于治疗由GSK3活性介导的疾病，如糖尿病、阿尔茨海默病和其他神经退行性疾病、肥胖症、动脉粥样硬化心血管疾病、原发性高血压、多囊卵巢综合症、X综合症、缺血、创伤性脑损伤、双相情感障碍、免疫缺陷或癌症。
• Isoxazole derivatives
  申请人：——

  公开号：US20040048908A1

  公开（公告）日：2004-03-11

  A compound represented by the formula (I) 1 wherein one of R 1 and R 2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: —OR 3 (wherein R 3 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.

  化合物的化学式为（I）1，其中R1和R2中的一个是氢原子或取代基，另一个是可选取代的环状基团；W是键或二价脂肪基碳氢基团；Y是式子：—OR3的基团（其中R3是氢原子、可选取代的碳氢基团、可选取代的杂环基团或可选取代的酰基基团），或可选酯化或酰胺化的羧基团，或其盐或前药。该化合物具有优异的促胰岛素分泌作用和降血糖作用，并且毒性低。因此，该化合物可用作制药剂，特别是用作糖尿病和糖尿病并发症的预防或治疗剂等。
• ISOXAZOLE DERIVATIVES
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1340749A1

  公开（公告）日：2003-09-03

  A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: -OR3 (wherein R3 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.

  由式（I）代表的化合物 其中 R1 和 R2 中的一个是氢原子或取代基，另一个是任选取代的环状基团； W 是键或二价脂族烃基； Y 是式中的一个基团：-OR3（其中 R3 是氢原子、任选取代的烃基、任选取代的杂环基或任选取代的酰基）或任选酯化或酰胺化的羧基，或其盐或其原药具有优异的促进胰岛素分泌作用和降血糖作用，且毒性低。因此，该化合物可用作药物制剂，特别是用于预防或治疗糖尿病和糖尿病并发症等。