3,4-dihydro-2H-quinoline-1-carbothioic acid anilide | 321973-32-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,4-dihydro-2H-quinoline-1-carbothioic acid anilide
• 英文别名: 3,4-Dihydro-2H-chinolin-1-thiocarbonsaeure-anilid；N-phenyl-1,2,3,4-tetrahydroquinoline-1-carbothioamide；N-phenyl-3,4-dihydro-2H-quinoline-1-carbothioamide
• CAS: 321973-32-4
• 化学式: C₁₆H₁₆N₂S
• 分子量: 268.382
• InChiKey: SUWCZYTUBWQYIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  47.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(2-氯乙基)吡咯烷 、 3,4-dihydro-2H-quinoline-1-carbothioic acid anilide 在 sodium hydride 作用下， 生成 N-Phenyl-3,4-dihydro-2H-quinoline-1-carboximidothioic acid 2-pyrrolidin-1-yl-ethyl ester
  参考文献：
  名称：

  Ranise; Bondavalli; Bruno, Il Farmaco, 1992, vol. 47, # 10, p. 1263 - 1283

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2,3,4-四氢喹啉 、 硫代异氰酸苯酯 以 乙醚 为溶剂， 反应 0.5h， 以64%的产率得到3,4-dihydro-2H-quinoline-1-carbothioic acid anilide
  参考文献：
  名称：

  Arene ruthenium metallacycles containing chelating thioamide ligands

  摘要：

  Cationic, chiral arene ruthenium complexes of the type [Ru(eta(6)-cym)(PPh3){kappa N-2,S-PhNC(S)R}]BPh4 were prepared in high yields by refluxing a mixture containing [(eta(6)-cym)RuCl2](2), Ph3P, PhNHC(S)R, NaBPh4 and Et3N in MeOH. A series of seven complexes with different thioamide ligands was prepared and fully characterised by spectroscopic methods including NMR spectroscopy and electrospray mass spectrometry. The solid-state structures of two complexes were determined by single crystal X-ray diffraction. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.12.015

文献信息

• A novel synthesis of functionalized sulfonamide derivatives using the reaction of substituted thiourea or oxime derivatives with N-(2,3-dibromopropyl)-aryl(alkyl)sulfonamides
  作者：Ali Monfared、Gholamhossein Khalili

  DOI：10.1007/s00706-022-02991-z

  日期：2023.1

  A facile synthesis of 1,3-difunctionalized 2-sulfonamidopropane derivatives by practical and novel reactions of N-(2,3-dibromopropyl)-aryl(alkyl)sulfonamide with substituted thiourea or oxime derivatives in the presence of MeONa without catalyst is described. Graphical abstract

  描述了在没有催化剂的情况下，通过N- (2,3-二溴丙基)-芳基(烷基)磺酰胺与取代的硫脲或肟衍生物在 MeONa 存在下的实用和新颖的反应，轻松合成 1,3-双官能化 2-磺酰胺基丙烷衍生物。 图形概要
• v. Braun; Deutsch, Chemische Berichte, 1912, vol. 45, p. 2511
  作者：v. Braun、Deutsch

  DOI：——

  日期：——
• Ranise; Bondavalli; Bruno, Il Farmaco, 1991, vol. 46, # 2, p. 317 - 338
  作者：Ranise、Bondavalli、Bruno、Schenone、Losasso、Costantino、Cenicola、Donnoli、Marmo

  DOI：——

  日期：——
• Arene ruthenium metallacycles containing chelating thioamide ligands
  作者：Cansu Alagöz、David J. Brauer、Fabian Mohr

  DOI：10.1016/j.jorganchem.2008.12.015

  日期：2009.4

  Cationic, chiral arene ruthenium complexes of the type [Ru(eta(6)-cym)(PPh3)kappa N-2,S-PhNC(S)R}]BPh4 were prepared in high yields by refluxing a mixture containing [(eta(6)-cym)RuCl2](2), Ph3P, PhNHC(S)R, NaBPh4 and Et3N in MeOH. A series of seven complexes with different thioamide ligands was prepared and fully characterised by spectroscopic methods including NMR spectroscopy and electrospray mass spectrometry. The solid-state structures of two complexes were determined by single crystal X-ray diffraction. (C) 2008 Elsevier B.V. All rights reserved.
• Ranise; Bondavalli; Bruno, Il Farmaco, 1992, vol. 47, # 10, p. 1263 - 1283
  作者：Ranise、Bondavalli、Bruno、Schenone、D'Amico、Parrillo、Marrazzo、Rossi

  DOI：——

  日期：——