3-(4-羟基-2-甲基苯基)丙-2-烯酸 | 103203-88-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 中文名称: 3-(4-羟基-2-甲基苯基)丙-2-烯酸
• 英文名称: 3-(4-Hydroxy-2-methylphenyl)prop-2-enoic acid
• CAS: 103203-88-9
• 化学式: C₁₀H₁₀O₃
• 分子量: 178.18
• InChiKey: ALVCCGIUMNTRJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPOUNDS AND COMPOSITIONS AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS
  申请人：BURKS Heather Elizabeth

  公开号：US20140235660A1

  公开（公告）日：2014-08-21

  The present invention relates to compounds of formula I: in which n, m, X, Y 1 , R 1 , R 2 , R 3 , R 4 and R 5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.

  本发明涉及式I的化合物： 其中n、m、X、Y1、R1、R2、R3、R4和R5在本发明概要中有定义；能够同时作为雌激素受体的强效拮抗剂和降解剂。本发明还提供了一种制备本发明化合物的方法，包括含有此类化合物的药物制剂以及使用这些化合物和组合物在管理与异常雌激素受体活性相关的疾病或紊乱的方法。
• BENZOTHIOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS
  申请人：NOVARTIS AG

  公开号：US20170112805A1

  公开（公告）日：2017-04-27

  The present invention relates to compounds of formula I: in which n, m, X, Y 1 , R 1 , R 2 , R 3 , R 4 and R 5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.

  本发明涉及公式I的化合物：其中n，m，X，Y1，R1，R2，R3，R4和R5在发明摘要中定义；能够同时作为雌激素受体的强拮抗剂和降解剂。本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂，以及使用这些化合物和组合物在管理与异常雌激素受体活性相关的疾病或紊乱的方法。
• RETARDATION FILM, A METHOD FOR PREPARING RETARDATION FILM AND POLARIZER COMPRISING THE RETARDATION FILM
  申请人：Kim Sin Young

  公开号：US20100068419A1

  公开（公告）日：2010-03-18

  There is provided a retardation film capable of adjusting an angle between a proceeding direction of a film and an optical axis of liquid crystal by employing an alignment layer formed of polymers including norbornene and improving thermal stability and photoreaction rate, a method for preparing the retardation film and a polarizer comprising the retardation film. The retardation film includes a substrate, an alignment layer formed on the substrate and made of polymers including norbornene, and an alignment layer fixing layer formed on the alignment layer and made of liquid crystal materials; the method for preparing a retardation film includes: forming a polymer layer by coating a substrate with a polymer solution including norbornene and drying the polymer solution, forming an alignment layer by irradiating the copolymer layer with linearly polarized ultraviolet rays in a predetermined direction relative to a proceeding direction of a film to give an orientation to the copolymer layer, forming a liquid crystal layer on the alignment layer by coating the alignment layer with a nematic liquid crystal solution and drying the nematic liquid crystal solution, and fixing the orientation of the liquid crystal layer by curing the liquid crystal layer; and the polarizer includes the retardation film and a polarizer film, both of which are stacked with each other. The retardation film has improved thermal stability and light reaction speed, and the retardation film whose optical axis has a desired orientation angle relative to a proceeding direction of the retardation film may be easily prepared through the irradiation of polarized ultraviolet rays.

  提供了一种减速膜，能够通过采用聚合物制备的取向层，包括诺博烯，改善热稳定性和光反应速率，调整膜的前进方向与液晶光轴之间的角度，以及制备减速膜的方法和包括减速膜的偏光器。减速膜包括基板，形成在基板上的取向层，由包括诺博烯的聚合物制成，以及形成在取向层上的取向层固定层，由液晶材料制成；制备减速膜的方法包括：通过涂覆聚合物溶液包括诺博烯并干燥聚合物溶液来形成聚合物层，通过辐射线偏振紫外线在相对于膜前进方向的预定方向上对共聚物层进行照射，使共聚物层定向，通过涂覆向列相液晶溶液并干燥向列相液晶溶液来在取向层上形成液晶层，通过固化液晶层来固定液晶层的方向；偏光器包括减速膜和偏光器膜，两者堆叠在一起。减速膜具有改善的热稳定性和光反应速度，通过极化紫外线的照射可以轻松地制备具有所需取向角度的光轴相对于减速膜前进方向的减速膜。
• DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS
  申请人：Takasu Hideki

  公开号：US20120283242A1

  公开（公告）日：2012-11-08

  The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R 1 and R 2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G 2 -, —N(lower alkyl)-G 2 -, —NH—CH 2 -G 2 -, —N(lower alkyl)-CH 2 -G 2 - or —CH 2 -G 2 -, [wherein G 2 binds to R 2 , G 2 -R 2 is bond-R 2 , phenylene-G 3 -R 2 , phenylene-G 4 -O—R 2 , phenylene-G 5 -NH—R 2 , phenylene-G 6 -N(lower alkyl)-R 2 or quinolinediyl-O—R 2 , the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G 3 -R 2 is —O-lower alkylene-R 2 or the like; G 4 -O— is lower alkylene-O— or the like; G 5 is lower alkylene; G 6 is lower alkylene].

  本发明提供了一种具有优异抗肿瘤效果的新型化合物。本发明的化合物由下述通式（1）表示，其中R1和R2为芳基或类似物；A为低级烷基；环X为可选取代的芳基；E为键或低级烯基；环Y为可选取代的杂环烷基，其中一个氮原子连接到相邻的羰基；G为—NH-G2-，—N(低级烷基)-G2-，—NH—CH2-G2-，—N(低级烷基)-CH2-G2-或—CH2-G2-，[其中G2与R2相连，G2-R2为键-R2，苯基-G3-R2，苯基-G4-O—R2，苯基-G5-NH—R2，苯基-G6-N(低级烷基)-R2或喹啉基-O—R2，所述苯基含有的苯基-含基团可选取代一个或多个取代基；G3-R2为—O-低级烷基-R2或类似物；G4-O—为低级烷基-O—或类似物；G5为低级烷基；G6为低级烷基]。
• 2,6-Di-tertiary butyl phenyl pentaerythritol spiro bis-phosphites enhancing the stability to heat and light of synthetic resins, stabilizer compositions comprising phenolic antioxidants and such phosphites, and synthetic resin compositions containing the same
  申请人：ADEKA ARGUS CHEMICAL CO., Ltd.

  公开号：EP0038876A1

  公开（公告）日：1981-11-04

  2,6-Di-tertiary butyl phenyl pentaerythritol spiro bis-phosphites are provided having the structure: wherein: R is alkyl having from one to six carbon atoms; R is methyl or ethyl; R2 is selected from the group consisting of alkyl having from one up to about eighteen carbon atoms; cycloalkyl having from three up to about twelve carbon atoms; and alkaryl and aryl having from six to about thirty carbon atoms; such groups substituted with from one to about four oxy ether-0- and/or carboxylic ester-COO-groups; the residue of a polyhydric alcohol having from two to about eighteen carbon atoms, and from two to about ten hydroxyl groups; and the residue of a polyphenol having from six to about eighteen carbon atoms and from two to about ten phenolic hydroxyl groups. Stabilizer compositions are provided comprising a phenolic antioxidant and such phosphites as well as synthetic resin compositions having an enhanced resistance to deterioration by heat and/or light due to the presence of such a phosphite and/or stabilizer composition.

  2,6-二叔丁基苯基季戊四醇螺双磷酸盐具有以下结构： 其中 R 是具有 1 至 6 个碳原子的烷基； R 是甲基或乙基 R2 选自具有 1 至约 18 个碳原子的烷基；具有 3 至约 12 个碳原子的环烷基；具有 6 至约 30 个碳原子的烷芳基和芳基；这些基团被 1 至约 4 个氧醚-0-和/或羧酸酯-COO-基团取代；具有 2 至约 18 个碳原子和 2 至约 10 个羟基的多元醇的残余物；以及具有 6 至约 18 个碳原子和 2 至约 10 个酚类羟基的多元酚的残余物。 稳定剂组合物包括酚类抗氧化剂和此类亚磷酸酯以及合成树脂组合物，由于此类亚磷酸酯和/或稳定剂组合物的存在，合成树脂组合物的耐热和/或耐光性得到增强。