4-(cyclopentylmethoxy)benzaldehyde | 118156-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(cyclopentylmethoxy)benzaldehyde
• 英文别名: p-cyclopentanemethoxybenzaldehyde
• CAS: 118156-62-0
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.269
• InChiKey: DZIBXWAXYOAXEO-UHFFFAOYSA-N

物化性质

• 沸点：
  337.3±15.0 °C(Predicted)
• 密度：
  1.075±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(cyclopentylmethoxy)benzaldehyde 在 sodium hydroxide 哌啶 、 sodium tetrahydroborate 、 N,N-二甲基甘氨酸 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 反应 4.0h， 生成 5-(4-(cyclopentylmethoxy)benzyl)thiazolidine-2,4-dione
  参考文献：
  名称：

  Structure–activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

  摘要：

  Depletion of calcium from the endoplasmic reticulum has shown to affect protein synthesis and cell proliferation. The anticancer effect of troglitazone was reported to be mediated by depletion of intracellular calcium stores resulting in inhibition of translation initiation. The unsaturated form of troglitazone displays similar anticancer properties in vitro. In this letter, we report our findings on the minimum structural requirements for both compounds to retain their calcium release and antiproliferative activities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.087
• 作为产物：
  描述：

  环戊基甲醇 、 对氟苯甲醛 在 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 4-(cyclopentylmethoxy)benzaldehyde
  参考文献：
  名称：

  Structure–activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

  摘要：

  Depletion of calcium from the endoplasmic reticulum has shown to affect protein synthesis and cell proliferation. The anticancer effect of troglitazone was reported to be mediated by depletion of intracellular calcium stores resulting in inhibition of translation initiation. The unsaturated form of troglitazone displays similar anticancer properties in vitro. In this letter, we report our findings on the minimum structural requirements for both compounds to retain their calcium release and antiproliferative activities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.087

文献信息

• NOVEL THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF
  申请人：Cho Hoon

  公开号：US20110269954A1

  公开（公告）日：2011-11-03

  The present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and the uses thereof. More specifically, the present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and a pharmaceutical composition comprising the same. The novel thiazolidinedione derivatives of formula (I) according to the present invention can be effectively used for the prevention or treatment of cardiovascular disease, gastrointestinal disease and renal disease by inhibiting the activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that decomposes prostaglandins as well as useful for the prevention of hair loss and the stimulation of hair growth, and osteogenic stimulation and wound healing.

  本发明涉及由以下式（I）表示的新型噻唑烷二酮衍生物及其用途。更具体地说，本发明涉及由以下式（I）表示的新型噻唑烷二酮衍生物以及包含其的药物组合物。根据本发明的式（I）的新型噻唑烷二酮衍生物可以通过抑制分解前列腺素的15-羟基前列腺素脱氢酶（15-PGDH）的活性，有效用于预防或治疗心血管疾病、胃肠道疾病和肾脏疾病，同时也用于预防脱发和促进头发生长，以及促进骨生成和伤口愈合。
• [EN] ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES<br/>[FR] AGENTS ANTIBACTÉRIENS : DÉRIVÉS ARYL MYXOPYRONINES
  申请人：UNIV RUTGERS

  公开号：WO2013192352A1

  公开（公告）日：2013-12-27

  The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

  该发明提供了以下公式的化合物：[公式 Ia、Ib 和 Ic] 及其盐，其中变量如规范中所述，以及包含公式 Ia-Ic 化合物的组合物、制备这种化合物的方法以及使用这种化合物的方法，例如作为细菌RNA聚合酶的抑制剂和抗菌剂。
• PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：US20150175541A1

  公开（公告）日：2015-06-25

  There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I′): (in the above-mentioned general formula (I′), W, Y, R 2 , R 3 , R 4 , and Y 4 are as described hereinabove), or pharmaceutically acceptable salts thereof.

  提供了一些化合物，具有优越的PHD2抑制作用，其通式表示为(I'):(在上述通式(I')中，W、Y、R2、R3、R4和Y4如上所述)，或其药学上可接受的盐。
• ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES
  申请人：RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

  公开号：US20150197512A1

  公开（公告）日：2015-07-16

  The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

  本发明提供了公式la、lb和Ic的化合物：[公式Ia、Ib和Ic]及其盐，其中变量如规范所述，以及包含化合物Ia-Ic的组合物，制备这种化合物的方法和使用这种化合物的方法，例如作为细菌RNA聚合酶的抑制剂和抗菌剂。
• Antibacterial agents: aryl myxopyronin derivatives
  申请人：RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

  公开号：US09315495B2

  公开（公告）日：2016-04-19

  The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

  本发明提供公式Ia、Ib和Ic的化合物及其盐，其中变量如说明书所述，以及包含化合物Ia-Ic的组合物、制备这样的化合物的方法和使用这样的化合物的方法，例如作为细菌RNA聚合酶的抑制剂和抗菌剂。