(R)-δ-tetradecalactone | 141980-54-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (R)-δ-tetradecalactone
• 英文别名: δ-tetradecalactone；(6R)-6-nonyloxan-2-one
• CAS: 141980-54-3
• 化学式: C₁₄H₂₆O₂
• 分子量: 226.359
• InChiKey: SKQYTJLYRIFFCO-CYBMUJFWSA-N

物化性质

• 沸点：
  322.8±10.0 °C(Predicted)
• 密度：
  0.916±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (R)-5-hydroxy-N-methyltetradecanamide 在 对甲苯磺酸 、 sodium hydroxide 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 27.0h， 生成 (R)-δ-tetradecalactone
  参考文献：
  名称：

  Enantioselective Synthesis of δ-Lactones with Lipase-Catalyzed Resolution and Mitsunobu Reaction

  摘要：

  Both enantiomers of a series of delta-lactones (e.g., delta-decalactone, delta-dodelactone, and delta-hexadecalactone) were synthesized stereoselectively by Novozym 435-catalyzed resolution. Furthermore, only (S)-enantiomers of delta-lactones were synthesized with a combination of Novozym 435-catalyzed resolution and Mitsunobu reaction.

  DOI：

  10.1080/00397911.2010.529230

文献信息

• Enantioselective Synthesis of <font>δ</font>-Lactones with Lipase-Catalyzed Resolution and Mitsunobu Reaction
  作者：Yasutaka Shimotori、Masakazu Aoyama、Tetsuo Miyakoshi

  DOI：10.1080/00397911.2010.529230

  日期：2012.3.1

  Both enantiomers of a series of delta-lactones (e.g., delta-decalactone, delta-dodelactone, and delta-hexadecalactone) were synthesized stereoselectively by Novozym 435-catalyzed resolution. Furthermore, only (S)-enantiomers of delta-lactones were synthesized with a combination of Novozym 435-catalyzed resolution and Mitsunobu reaction.