(3aR,3bS,5S,7aS,7bS,8S,9aS,12aS,12bS,12cR)-5-(tert-Butyl-dimethyl-silanyloxy)-10-eth-(E)-ylidene-2,2,7a,9a-tetramethyl-8-triethylsilanyloxy-hexadecahydro-1,3-dioxa-dicyclopenta[a,l]phenanthren-11-one | 871247-63-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (3aR,3bS,5S,7aS,7bS,8S,9aS,12aS,12bS,12cR)-5-(tert-Butyl-dimethyl-silanyloxy)-10-eth-(E)-ylidene-2,2,7a,9a-tetramethyl-8-triethylsilanyloxy-hexadecahydro-1,3-dioxa-dicyclopenta[a,l]phenanthren-11-one
• 英文别名: (1S,2R,6R,7S,9S,12S,13S,14S,16S,17E,20S)-9-[tert-butyl(dimethyl)silyl]oxy-17-ethylidene-4,4,12,16-tetramethyl-14-triethylsilyloxy-3,5-dioxapentacyclo[11.7.0.02,6.07,12.016,20]icosan-18-one
• CAS: 871247-63-1
• 化学式: C₃₆H₆₄O₅Si₂
• 分子量: 633.072
• InChiKey: CTYZFBGNYBSVIA-FXRNMJQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.29
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3aR,3bS,5S,7aS,7bS,8S,9aS,12aS,12bS,12cR)-5-(tert-Butyl-dimethyl-silanyloxy)-10-eth-(E)-ylidene-2,2,7a,9a-tetramethyl-8-triethylsilanyloxy-hexadecahydro-1,3-dioxa-dicyclopenta[a,l]phenanthren-11-one 在 吡啶 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 叔丁基锂 、 copper(l) cyanide 作用下， 以 四氢呋喃 、 乙醚 、 正戊烷 为溶剂， 反应 7.5h， 生成
  参考文献：
  名称：

  The Synthesis and Preliminary Biological Evaluation of a Novel Steroid with Neurotrophic Activity:  NGA0187

  摘要：

  A full account of the total synthesis of neurotrophic compound NGA0187 is provided. A key feature of the synthesis involved the direct selective oxidation of 6 alpha,7 beta-diol to install the unusual 6,7-ketol moiety and stereoselective conjugate addition of vinyl cuprate to enone. A preliminary evaluation of its ability to stimulate the neurite outgrowth was also evaluated with PC12 cell.

  DOI：

  10.1021/jo051556d
• 作为产物：
  描述：

  (3S,5S,6R,7R,8S,9S,10S,11S,13S,14S)-10,13-dimethyl-3,11-bis(triethylsilyloxy)spiro[1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-17,2'-1,3-dioxolane]-6,7-diol 在 2,6-二甲基吡啶 、 叔丁基过氧化氢 、 selenium(IV) oxide 、 potassium tert-butylate 、 戴斯-马丁氧化剂 、 溶剂黄146 、 (+)-10-camphorsulfonic acid 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 (3aR,3bS,5S,7aS,7bS,8S,9aS,12aS,12bS,12cR)-5-(tert-Butyl-dimethyl-silanyloxy)-10-eth-(E)-ylidene-2,2,7a,9a-tetramethyl-8-triethylsilanyloxy-hexadecahydro-1,3-dioxa-dicyclopenta[a,l]phenanthren-11-one
  参考文献：
  名称：

  The Synthesis and Preliminary Biological Evaluation of a Novel Steroid with Neurotrophic Activity:  NGA0187

  摘要：

  A full account of the total synthesis of neurotrophic compound NGA0187 is provided. A key feature of the synthesis involved the direct selective oxidation of 6 alpha,7 beta-diol to install the unusual 6,7-ketol moiety and stereoselective conjugate addition of vinyl cuprate to enone. A preliminary evaluation of its ability to stimulate the neurite outgrowth was also evaluated with PC12 cell.

  DOI：

  10.1021/jo051556d

文献信息

• The Synthesis and Preliminary Biological Evaluation of a Novel Steroid with Neurotrophic Activity:  NGA0187
  作者：Zihao Hua、David A. Carcache、Yuan Tian、Yue-Ming Li、Samuel J. Danishefsky

  DOI：10.1021/jo051556d

  日期：2005.11.1

  A full account of the total synthesis of neurotrophic compound NGA0187 is provided. A key feature of the synthesis involved the direct selective oxidation of 6 alpha,7 beta-diol to install the unusual 6,7-ketol moiety and stereoselective conjugate addition of vinyl cuprate to enone. A preliminary evaluation of its ability to stimulate the neurite outgrowth was also evaluated with PC12 cell.