N-phenoxy-3-[(quinolin-4-ylmethyl)amino]thiophene-2-carboxamide | 880466-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-phenoxy-3-[(quinolin-4-ylmethyl)amino]thiophene-2-carboxamide
• 英文别名: N-Phenoxy-3-[(4-quinolinylmethyl)amino]-2-thiophenecarboxamide；N-phenoxy-3-(quinolin-4-ylmethylamino)thiophene-2-carboxamide
• CAS: 880466-61-5
• 化学式: C₂₁H₁₇N₃O₂S
• 分子量: 375.451
• InChiKey: XKHSLFYSYFNORE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  91.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• (Hydrazido)(amino)thiophene compounds
  申请人：Crew Andrew

  公开号：US20060063773A1

  公开（公告）日：2006-03-23

  Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.

  由化学式（I）表示的化合物：或其药学上可接受的盐或N-氧化物，其中A和J在此处被定义，可用于治疗肿瘤和癌症，如肥大细胞增多症/肥大细胞白血病、胃肠道间质瘤（GIST）、生殖细胞肿瘤、小细胞肺癌（SCLC）、鼻窦自然杀伤/ T细胞淋巴瘤、睾丸癌（精原细胞瘤）、甲状腺癌、恶性黑色素瘤、卵巢癌、腺样囊性癌、急性髓系白血病（AML）、乳腺癌、儿童T细胞急性淋巴细胞白血病、神经母细胞瘤、肥大细胞白血病、血管肉瘤、间变性大细胞淋巴瘤、子宫内膜癌和前列腺癌。
• US7388012B2
  申请人：——

  公开号：US7388012B2

  公开（公告）日：2008-06-17
• [EN] (HYDRAZIDO) (AMINO) THIOPHENE COMPOUNDS<br/>[FR] COMPOSES D'(HYDRAZIDO) (AMINO) THIOPHENE
  申请人：OSI PHARM INC

  公开号：WO2006034075A1

  公开（公告）日：2006-03-30

  Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.