2,2-Difluoro-4-methyl-1-phenyl-pent-4-en-1-one | 373393-26-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-Difluoro-4-methyl-1-phenyl-pent-4-en-1-one
• 英文别名: 2,2-Difluoro-4-methyl-1-phenyl-4-penten-1-one；2,2-difluoro-4-methyl-1-phenylpent-4-en-1-one
• CAS: 373393-26-1
• 化学式: C₁₂H₁₂F₂O
• 分子量: 210.223
• InChiKey: WEYZDIZBMIJUMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  碘苯 、 Tributyl-[2,2-difluoro-1-(2-methyl-allyloxy)-vinyl]-stannane 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 copper(l) iodide 、 三(2-呋喃基)膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 以60%的产率得到2,2-Difluoro-4-methyl-1-phenyl-pent-4-en-1-one
  参考文献：
  名称：

  A direct and useful route to difluoroacylsilanes and difluoroacylstannanes and their potential for the generation of structurally diverse difluoroketones

  摘要：

  Allyl trifluoroethyl ethers 2a-2d were prepared; each underwent efficient dehydrofluorination/metallation and trapping to afford a range of difluoroenol silanes and stannanes which rearranged easily and efficiently to the acyl metals. Fluoride-mediated benzylation and allylation of an acylsilane, and Stille coupling of the vinyl- and acyl-stannane were achieved in moderate to good yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01220-5

文献信息

• A direct and useful route to difluoroacylsilanes and difluoroacylstannanes and their potential for the generation of structurally diverse difluoroketones
  作者：Maxime R Garayt、Jonathan M Percy

  DOI：10.1016/s0040-4039(01)01220-5

  日期：2001.9

  Allyl trifluoroethyl ethers 2a-2d were prepared; each underwent efficient dehydrofluorination/metallation and trapping to afford a range of difluoroenol silanes and stannanes which rearranged easily and efficiently to the acyl metals. Fluoride-mediated benzylation and allylation of an acylsilane, and Stille coupling of the vinyl- and acyl-stannane were achieved in moderate to good yield. (C) 2001 Elsevier Science Ltd. All rights reserved.