tert-butyl N-[N-[(2-methylpropan-2-yl)oxycarbonyl]-N'-[[1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]methyl]carbamimidoyl]carbamate | 744202-35-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: tert-butyl N-[N-[(2-methylpropan-2-yl)oxycarbonyl]-N'-[[1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]methyl]carbamimidoyl]carbamate
• CAS: 744202-35-5
• 化学式: C₂₁H₃₉N₅O₅Si
• 分子量: 469.657
• InChiKey: IUDGLTWQNQCYGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[N-[(2-methylpropan-2-yl)oxycarbonyl]-N'-[[1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]methyl]carbamimidoyl]carbamate 在 正丁基锂 、 仲丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成 tert-butyl N-[N'-[[5-chlorosulfonyl-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate
  参考文献：
  名称：

  A novel synthetic approach towards 2-guanidinomethyl-4(5)-sulfamoylimidazoles

  摘要：

  A library of 2-guanidinomethyl-4(5)-sulfamoylimidazoles was synthesised in a convergent manner by introducing sulfonyl chloride group via a trianion electrophilic sulfinylation of suitably protected 2-guanidinomethyl imidazoles. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.05.143
• 作为产物：
  描述：

  1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carbaldehyde 在 吡啶 、 盐酸羟胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 tert-butyl N-[N-[(2-methylpropan-2-yl)oxycarbonyl]-N'-[[1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]methyl]carbamimidoyl]carbamate
  参考文献：
  名称：

  A novel synthetic approach towards 2-guanidinomethyl-4(5)-sulfamoylimidazoles

  摘要：

  A library of 2-guanidinomethyl-4(5)-sulfamoylimidazoles was synthesised in a convergent manner by introducing sulfonyl chloride group via a trianion electrophilic sulfinylation of suitably protected 2-guanidinomethyl imidazoles. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.05.143

文献信息

• A novel synthetic approach towards 2-guanidinomethyl-4(5)-sulfamoylimidazoles
  作者：Steve Price、Richard Bull、Sue Cramp、Sophie Gardan、Marco van den Heuvel、David Neighbour、Susan E. Osbourn、Iwan J.P. de Esch、Christoph L. Buenemann

  DOI：10.1016/j.tetlet.2004.05.143

  日期：2004.7

  A library of 2-guanidinomethyl-4(5)-sulfamoylimidazoles was synthesised in a convergent manner by introducing sulfonyl chloride group via a trianion electrophilic sulfinylation of suitably protected 2-guanidinomethyl imidazoles. (C) 2004 Elsevier Ltd. All rights reserved.