(S)-2-{(R)-2-[{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propionyl}-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-amino]-3-phenyl-propionylamino}-propionic acid benzyl ester | 370579-85-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-{(R)-2-[{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propionyl}-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-amino]-3-phenyl-propionylamino}-propionic acid benzyl ester
• 英文别名: benzyl (2S)-2-[[(2R)-2-[[(2S)-2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]propanoyl]-[[(2R,3R,4S,5R,6S)-6-methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]amino]-3-phenylpropanoyl]amino]propanoate
• CAS: 370579-85-4
• 化学式: C₆₇H₇₀N₄O₁₂
• 分子量: 1123.31
• InChiKey: MIOMHCXUNRVUHN-VGPFGQATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  83
• 可旋转键数：
  28
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  189
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  (S)-2-{(R)-2-[{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propionyl}-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-amino]-3-phenyl-propionylamino}-propionic acid benzyl ester 在 palladium on activated charcoal 哌啶 、 氢气 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-2-{(R)-2-[[(S)-2-(2-Amino-acetylamino)-propionyl]-((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-amino]-3-phenyl-propionylamino}-propionic acid
  参考文献：
  名称：

  Synthesis of novel amino acid carbohydrate hybrids via Mitsunobu glycosylation of nitrobenzenesulfonamides

  摘要：

  Amino acid derived 2-nitrobenzenesulfonamides were successfully condensed under Mitsunobu conditions with the primary alcohol of various saccharide and nucleoside derivatives to furnish the fully protected hybrids in excellent yield. One such hybrid was incorporated into a short peptide sequence in good overall yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01062-0
• 作为产物：
  描述：

  (S)-2-{(R)-2-[(2-Nitro-benzenesulfonyl)-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-amino]-3-phenyl-propionylamino}-propionic acid benzyl ester 在 2,6-二叔丁基吡啶 、 苯硫酚 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-2-{(R)-2-[{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propionyl}-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-amino]-3-phenyl-propionylamino}-propionic acid benzyl ester
  参考文献：
  名称：

  Synthesis of novel amino acid carbohydrate hybrids via Mitsunobu glycosylation of nitrobenzenesulfonamides

  摘要：

  Amino acid derived 2-nitrobenzenesulfonamides were successfully condensed under Mitsunobu conditions with the primary alcohol of various saccharide and nucleoside derivatives to furnish the fully protected hybrids in excellent yield. One such hybrid was incorporated into a short peptide sequence in good overall yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01062-0

文献信息

• Synthesis of novel amino acid carbohydrate hybrids via Mitsunobu glycosylation of nitrobenzenesulfonamides
  作者：John J. Turner、Dmitri V. Filippov、Mark Overhand、Gijs A. van der Marel、Jacques H. van Boom

  DOI：10.1016/s0040-4039(01)01062-0

  日期：2001.8

  Amino acid derived 2-nitrobenzenesulfonamides were successfully condensed under Mitsunobu conditions with the primary alcohol of various saccharide and nucleoside derivatives to furnish the fully protected hybrids in excellent yield. One such hybrid was incorporated into a short peptide sequence in good overall yield. (C) 2001 Elsevier Science Ltd. All rights reserved.