3-(氯甲基)-5-环丁基-1,2,4-恶二唑 | 259683-88-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 3-(氯甲基)-5-环丁基-1,2,4-恶二唑
• 英文名称: 3-(Chloromethyl)-5-cyclobutyl-1,2,4-oxadiazole
• CAS: 259683-88-0
• 化学式: C₇H₉ClN₂O
• mdl: MFCD00728735
• 分子量: 172.61
• InChiKey: OHNJTQRSUDKTKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

文献信息

• Alpha-helical mimetics
  申请人：Lessene Guillaume Laurent

  公开号：US20080153802A1

  公开（公告）日：2008-06-26

  Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

  公开了模拟α螺旋肽的苯甲酰脲衍生物，这些衍生物模拟BH3-仅蛋白，含有它们的组合物，它们与细胞靶向基团的结合，以及它们在调节细胞死亡中的用途。苯甲酰脲衍生物能够结合并中和促生存的Bcl-2蛋白。还描述了在治疗和/或预防与细胞死亡失调相关的疾病或症状中使用苯甲酰脲衍生物。
• TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1177176B1

  公开（公告）日：2006-04-19
• US7005440B1
  申请人：——

  公开号：US7005440B1

  公开（公告）日：2006-02-28
• US7956216B2
  申请人：——

  公开号：US7956216B2

  公开（公告）日：2011-06-07
• [EN] TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS<br/>[FR] DERIVES D'ACIDE TRI-ARYLE EN TANT QUE LIGANDS POUR RECEPTEUR DE PEROXISOME A ACTIVATION PAR PROLIFERATEUR (PPAR)
  申请人：AVENTIS PHARM PROD INC

  公开号：WO2000064876A1

  公开（公告）日：2000-11-02

  This invention is directed to triaryl acid derivatives of formula (I) and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor. In formula (I), (a), (b), and (c) are independently aryl, fused arylcycloalkenyl, fused arylcycloalkyl, fused arylheterocyclenyl, fused arylheterocyclyl, heteroaryl, fused heteroarylcycloalkemyl, fused heteroarylcycloalkyl, fused heteroarylheterocyclenyl, or fused heteroarylheterocyclyl; A is -O-, -S-, -SO-, -SO2-, -NR13-, -C(O)-, -N(R14)C(O)-, -C(O)N(R15)-, -N(R14)C(O)N(R15)-, -C(R14)=N-, (d), (e), (f) a chemical bond, (g) or (h); B is -O-, -S-, -SO-, -SO2-, -NR17-, a chemical bond, ethynylene, -C(O)-, -N(R18)C(O)-, or -C(O)NR18-; D is -O-, -S-, -NR19-, a chemical bond, ethynylene, -C(O)-, -N(R20)C(O)-, or -C(O)N(R20)-; E is a chemical bond or an ethylene group; Z is R21O2C-, R21OC-, cyclo-imide, -CN, R21O2SHNCO-, R21O2SHN-, (R21)2NCO-, R21O-2,4-thiazolidinedionyl, or tetrazolyl.