(+/-)-1-(4-benzyloxyphenyl)-5,6-dihydroxyhexan-1-one | 470665-21-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+/-)-1-(4-benzyloxyphenyl)-5,6-dihydroxyhexan-1-one
• 英文别名: 5,6-Dihydroxy-1-(4-phenylmethoxyphenyl)hexan-1-one
• CAS: 470665-21-5
• 化学式: C₁₉H₂₂O₄
• 分子量: 314.381
• InChiKey: WLENPEHZVOMMGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (+/-)-1-(4-benzyloxyphenyl)-5,6-dihydroxyhexan-1-one 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 10.0h， 以60%的产率得到6-(4-hydroxyphenyl)hexane-1,2,6-triol
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity of Hydroxyalkyl- and Hydroxyacyl-phenols and Their Benzyl Ethers

  摘要：

  New phenolic compounds with hydrophilic side chains were prepared from 4-benzyloxybenzaldehyde and alkenyl magnesium bromides, followed by Sharpless dihydroxylation and hydrogenolytic removal of the benzyl group. The resulting compounds were tested in an agar diffusion assay against gram positive bacteria, gram negative bacteria, and against the fungi Candida glabrata and Aspergillus niger.

  DOI：

  10.1002/1521-4184(200203)335:2/3<94::aid-ardp94>3.0.co;2-w
• 作为产物：
  描述：

  (+/-)-1-(4-benzyloxyphenyl)hex-5-en-1-ol 在 α-AD mix {K4[Fe(CN)6], OsO4, Na2CO3, (DHQ)2-PHAL} 作用下， 以 水 、 叔丁醇 为溶剂， 反应 12.0h， 以42%的产率得到(+/-)-1-(4-benzyloxyphenyl)-5,6-dihydroxyhexan-1-one
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity of Hydroxyalkyl- and Hydroxyacyl-phenols and Their Benzyl Ethers

  摘要：

  New phenolic compounds with hydrophilic side chains were prepared from 4-benzyloxybenzaldehyde and alkenyl magnesium bromides, followed by Sharpless dihydroxylation and hydrogenolytic removal of the benzyl group. The resulting compounds were tested in an agar diffusion assay against gram positive bacteria, gram negative bacteria, and against the fungi Candida glabrata and Aspergillus niger.

  DOI：

  10.1002/1521-4184(200203)335:2/3<94::aid-ardp94>3.0.co;2-w

文献信息

• Synthesis and Antimicrobial Activity of Hydroxyalkyl- and Hydroxyacyl-phenols and Their Benzyl Ethers
  作者：Jürgen Krauß、D. Unterreitmeier

  DOI：10.1002/1521-4184(200203)335:2/3<94::aid-ardp94>3.0.co;2-w

  日期：2002.3

  New phenolic compounds with hydrophilic side chains were prepared from 4-benzyloxybenzaldehyde and alkenyl magnesium bromides, followed by Sharpless dihydroxylation and hydrogenolytic removal of the benzyl group. The resulting compounds were tested in an agar diffusion assay against gram positive bacteria, gram negative bacteria, and against the fungi Candida glabrata and Aspergillus niger.