sec-Dodecyl-2-hydroxyethylether | 5940-87-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sec-Dodecyl-2-hydroxyethylether
• 英文别名: 2-(1-methyl-undecyloxy)-ethanol；2-Dodecan-2-yloxyethanol
• CAS: 5940-87-4
• 化学式: C₁₄H₃₀O₂
• 分子量: 230.391
• InChiKey: PSTFONOFPHPVAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  sec-Dodecyl-2-hydroxyethylether 在 氯磺酸 作用下， 以 二氯甲烷 为溶剂， 以61.9 g的产率得到2-Dodecan-2-yloxyethyl hydrogen sulfate
  参考文献：
  名称：

  WO2024064645A1

  摘要：

  公开号：
• 作为产物：
  描述：

  乙二醇 、 1-十二烯十二碳烯α-十二碳烯α-十二碳烯 在 alluminium silicate 作用下， 生成 sec-Dodecyl-2-hydroxyethylether
  参考文献：
  名称：

  WO2024064645A1

  摘要：

  公开号：

文献信息

• METHODS, COMPOSITIONS, AND FORMULATIONS FOR PREVENTING OR REDUCING ADVERSE EFFECTS IN A PATIENT
  申请人：Stover Richard R.

  公开号：US20080175891A1

  公开（公告）日：2008-07-24

  The present invention provides transdermal administration of AICA riboside, or a prodrugs, analogs, or salts thereof, and/or a blood clotting inhibitor for preventing or reducing adverse side effects in a patient. The type of patient that may benefit includes a patient with decreased left ventricular function, a patient with a prior myocardial infarction, a patient undergoing non-vascular surgery, or a fetus during labor and delivery.

  本发明提供了通过经皮途径给予AICA核糖苷，或其前药、类似物或盐，和/或血液凝块抑制剂以预防或减少患者的不良副作用。可能受益的患者类型包括左心室功能减退的患者、先前发生心肌梗死的患者、接受非血管手术的患者，或分娩期间的胎儿。
• Pharmaceutical composition and method of manufacturing
  申请人：Speier Gary J.

  公开号：US10092611B1

  公开（公告）日：2018-10-09

  The present invention provides for methods of obtaining an extract of Cannabis plant material as well as subsequent processing of the extract to provide a concentrate of Cannabis. The present invention also provides for pharmaceutical dosage forms (e.g., oral thin films and transdermal patches) that include the concentrate (or extract) of Cannabis, as well as methods of medical treatment that include administering the pharmaceutical dosage forms.

  本发明提供了获得大麻植物材料提取物的方法，以及对提取物进行后续加工以提 供大麻浓缩物的方法。本发明还提供了包括大麻浓缩物（或提取物）的药物剂型（如口服薄膜和透皮贴剂），以及包括施用药物剂型的医疗方法。
• Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
  申请人：——

  公开号：US20030198662A1

  公开（公告）日：2003-10-23

  Composition of matter for application to a body surface or membrane to administer a N-(2,5-Disubstituted phenyl)-N′-(3-substituted phenyl)-N′-methyl guanidine by permeation through the body surface or membrane, the composition comprising the guanidine compound to be administered, at a therapeutically effective rate, optionally in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of a guanidine for the prevention of neuropathic pain, neuropsychological deficits resulting from cardiac surgery (CABG), and other neurological disorders.

  用于体表或体膜的物质组合物，以通过体表或体膜渗透给药N-(2,5-二取代苯基)-N′-(3-取代苯基)-N′-甲基胍，该组合物包括待给药的胍化合物，以治疗有效率给药，可选择与渗透促进剂或混合物结合使用。本发明还公开了透皮给药胍的给药装置和方法，用于预防神经性疼痛、心脏手术（CABG）导致的神经心理障碍以及其他神经系统疾病。
• Film-forming agent for drug delivery and preparation for percutaneous administration containing the same
  申请人：——

  公开号：US20030199644A1

  公开（公告）日：2003-10-23

  The present invention relates to a film-forming agent which forms a film on the skin, and also to a preparation for percutaneous administration containing the film-forming agent and active ingredient. The transdermal preparation including the film-forming agent of the present invention and active ingredient exhibits excellent elasticity and flexibility, shows superior adhesion power when formed on the skin, and forms non-sticky film.

  本发明涉及一种可在皮肤上成膜的成膜剂，还涉及一种含有该成膜剂和活性成分的经皮给药制剂。包含本发明成膜剂和活性成分的透皮制剂具有良好的弹性和柔韧性，在皮肤上成膜时显示出卓越的附着力，并形成不粘的薄膜。
• Novel formulations for the transdermal administration of fenoldopam
  申请人：——

  公开号：US20040057987A1

  公开（公告）日：2004-03-25

  Composition of matter for application to a body surface or membrane to administer fenoldopam by permeation through the body surface or membrane, the composition comprising fenoldopam to be administered, at a therapeutically effective rate, in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of fenoldopam for the treatment of hypertension, congestive heart failure, and chronic and acute renal failure.

  用于体表或体膜的物质组合物，以通过体表或体膜渗透的方式给药芬诺多泮；该组合物包含芬诺多泮，以治疗有效率与渗透促进剂或混合物结合给药。本发明还公开了用于治疗高血压、充血性心力衰竭、慢性和急性肾功能衰竭的非诺多泮透皮给药装置和方法。