C-[1-(1,5-Dimethyl-1H-indol-3-yl)-cyclopentyl]-methylamine | 145132-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: C-[1-(1,5-Dimethyl-1H-indol-3-yl)-cyclopentyl]-methylamine
• 英文别名: [1-(1,5-Dimethylindol-3-yl)cyclopentyl]methanamine
• CAS: 145132-15-6
• 化学式: C₁₆H₂₂N₂
• 分子量: 242.364
• InChiKey: TVKDYGJCEWGTRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  31
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  C-[1-(1,5-Dimethyl-1H-indol-3-yl)-cyclopentyl]-methylamine 、 2,2,2-trichloro-N-(2,6-diisopropylphenyl)acetamide 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以58%的产率得到1-[[1-(1,5-二甲基吲哚-3-基)环戊基]甲基]-3-[2,6-二(丙-2-基)苯基]脲
  参考文献：
  名称：

  New indole derivatives as ACAT inhibitors: synthesis and structure-activity relationships

  摘要：

  A series of ureas containing the indole group were synthesized and assessed for their ability to inhibit arterial and intestinal ACAT and to lower plasma total cholesterol in a cholesterol-fed rat model. The structural modulations carried out in this series led to compounds which proved to be very active in both the inhibition of aortic ACAT in vitro and the inhibition of rat cholesterol intestinal absorption in vivo. Several compounds from this series exhibit a remarkable hypocholesterolaemic effect with ED(25) less than 0.1 mg/kg po.

  DOI：

  10.1016/0223-5234(96)80445-4
• 作为产物：
  描述：

  5-甲基吲哚-3-乙腈 在 sodium hydroxide 、 lithium aluminium tetrahydride 、 苄基三甲基氢氧化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 二甲基亚砜 为溶剂， 反应 7.0h， 生成 C-[1-(1,5-Dimethyl-1H-indol-3-yl)-cyclopentyl]-methylamine
  参考文献：
  名称：

  New indole derivatives as ACAT inhibitors: synthesis and structure-activity relationships

  摘要：

  A series of ureas containing the indole group were synthesized and assessed for their ability to inhibit arterial and intestinal ACAT and to lower plasma total cholesterol in a cholesterol-fed rat model. The structural modulations carried out in this series led to compounds which proved to be very active in both the inhibition of aortic ACAT in vitro and the inhibition of rat cholesterol intestinal absorption in vivo. Several compounds from this series exhibit a remarkable hypocholesterolaemic effect with ED(25) less than 0.1 mg/kg po.

  DOI：

  10.1016/0223-5234(96)80445-4