6¹,6³-Di-O-methylsulfonyl-cG₇ permethylate | 139622-78-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6¹,6³-Di-O-methylsulfonyl-cG₇ permethylate
• 英文别名: 6(A),6(C)-di-O-methylsulfonyl-2(A),2(B),2(C),2(D),2(E),2(F),2(G),3(A),3(B),3(C),3(D),3(E),3(F),3(G),6(B),6(D),6(E),6(F),6(G)-nonadeca-O-methyl-β-CD；[(1R,3R,5R,6R,8R,10R,11R,13R,15R,16R,18R,20R,21R,23R,25R,26R,28R,30R,31R,33R,35R,36S,37R,38S,39R,40S,41R,42S,43R,44S,45R,46S,47R,48S,49R)-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecamethoxy-10,20,25,30,35-pentakis(methoxymethyl)-5-(methylsulfonyloxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-15-yl]methyl methanesulfonate
• CAS: 139622-78-9
• 化学式: C₆₃H₁₁₂O₃₉S₂
• 分子量: 1557.69
• InChiKey: KNFIRHACWRPIBF-MWDJDSKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  104
• 可旋转键数：
  30
• 环数：
  21.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  408
• 氢给体数：
  0
• 氢受体数：
  39

反应信息

• 作为反应物：
  描述：

  6¹,6³-Di-O-methylsulfonyl-cG₇ permethylate 在 H₂₄Na₂O₁₂S 作用下， 以 二甲基亚砜 为溶剂， 以65%的产率得到6(A),6(C)-dideoxy-6(A),6(C)-epithio-2(A),2(B),2(C),2(D),2(E),2(F),2(G),3(A),3(B),3(C),3(D),3(E),3(F),3(G),6(B),6(D),6(E),6(F),6(G)-nonadeca-O-methyl-β-CD
  参考文献：
  名称：

  Armspach, Dominique; Matt, Dominique; Toupet, Loic, Angewandte Chemie - International Edition, 2009, vol. 48, p. 4555 - 4558

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基磺酰氯 、 heptakis(2,3-di-O-methyl)-6^B,6^D,6^E,6^F,6^G-penta-O-methyl-β-cyclodextrin 在 吡啶 作用下， 以78.3%的产率得到6¹,6³-Di-O-methylsulfonyl-cG₇ permethylate
  参考文献：
  名称：

  Preparation of di-O-triphenylmethyl-(trityl)-cyclomalto-hexaoses and -cyclomaltoheptaoses and characterization of three positional isomers of each by the “hex-5-enose degradation”

  摘要：

  Regioisomeric 6l,6n-di-O-trityl-cyclomaltohexaoses (cG6s) or -cyclomaltoheptaoses (cG7s) were prepared by the reaction of cyclomaltohexaose (1, cG6) or cylomaltoheptaose (5, cG7) with chlorotriphenylmethane methane in pyridine and isolation by h.p.l.c. The regiochemical determination of each three ditrityl-substituted substituted derivatives has been accomplished by the "hex-5-enose degradation", followed by measurement of their f.a.b.-mass spectra.

  DOI：

  10.1016/0008-6215(92)80001-h

文献信息

• Preparation of di-O-triphenylmethyl-(trityl)-cyclomalto-hexaoses and -cyclomaltoheptaoses and characterization of three positional isomers of each by the “hex-5-enose degradation”
  作者：Toshiko Tanimoto、Mari Tanaka、Tomoko Yuno、Kyoko Koizumi

  DOI：10.1016/0008-6215(92)80001-h

  日期：1992.1

  Regioisomeric 6l,6n-di-O-trityl-cyclomaltohexaoses (cG6s) or -cyclomaltoheptaoses (cG7s) were prepared by the reaction of cyclomaltohexaose (1, cG6) or cylomaltoheptaose (5, cG7) with chlorotriphenylmethane methane in pyridine and isolation by h.p.l.c. The regiochemical determination of each three ditrityl-substituted substituted derivatives has been accomplished by the "hex-5-enose degradation", followed by measurement of their f.a.b.-mass spectra.
• Armspach, Dominique; Matt, Dominique; Toupet, Loic, Angewandte Chemie - International Edition, 2009, vol. 48, p. 4555 - 4558
  作者：Armspach, Dominique、Matt, Dominique、Toupet, Loic

  DOI：——

  日期：——