(Z)-2-hydroxy-3-(naphthalen-1-yl)-acrylic acid | 1393792-66-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (Z)-2-hydroxy-3-(naphthalen-1-yl)-acrylic acid
• 英文别名: (Z)-2-hydroxy-3-naphthalen-1-ylprop-2-enoic acid
• CAS: 1393792-66-9
• 化学式: C₁₃H₁₀O₃
• 分子量: 214.221
• InChiKey: PHKPWBBGPPMVHK-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (Z)-1-acetyl-3-(naphthalene-1-yl-methylene)-piperazine-2,5-dione 在 盐酸 、 水 作用下， 反应 4.0h， 以95%的产率得到(Z)-2-hydroxy-3-(naphthalen-1-yl)-acrylic acid
  参考文献：
  名称：

  Novel approach to the synthesis of aliphatic and aromatic α-keto acids

  摘要：

  A new practical and efficient synthesis of alpha-keto acids was accomplished starting from the synthon 1,4-diacetylpiperazine-2,5-dione. The synthesis encompasses both aromatic and aliphatic substrates proving to be versatile and innovative with excellent carbon economy and recycling of the glycine by-product. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.078

文献信息

• Novel approach to the synthesis of aliphatic and aromatic α-keto acids
  作者：Daniele Balducci、Philip A. Conway、Giulia Sapuppo、Helge Müller-Bunz、Francesca Paradisi

  DOI：10.1016/j.tet.2012.06.078

  日期：2012.9

  A new practical and efficient synthesis of alpha-keto acids was accomplished starting from the synthon 1,4-diacetylpiperazine-2,5-dione. The synthesis encompasses both aromatic and aliphatic substrates proving to be versatile and innovative with excellent carbon economy and recycling of the glycine by-product. (C) 2012 Elsevier Ltd. All rights reserved.