6-(2-Hydroxy-3-(18F)fluoropropyloxy)-2-(4-(methylamino)phenyl)quinoline | 1374108-17-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(2-Hydroxy-3-(18F)fluoropropyloxy)-2-(4-(methylamino)phenyl)quinoline
• 英文别名: 1-(18F)fluoranyl-3-[2-[4-(methylamino)phenyl]quinolin-6-yl]oxypropan-2-ol
• CAS: 1374108-17-4
• 化学式: C19H19FN2O2
• 分子量: 325.4
• InChiKey: QXGZMQJLUUBGMN-LRFGSCOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• TAU IMAGING PROBE
  申请人：CLINO LTD.

  公开号：US20160008494A1

  公开（公告）日：2016-01-14

  An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R a and R b are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.
• RADIOLABELLING METHOD
  申请人：GE Healthcare Limited

  公开号：US20170106104A1

  公开（公告）日：2017-04-20

  The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to automated methods for the preparation and purification of 18 F-labelled tau imaging radiotracers. Also provided are interchangeable cassettes useful in the methods, and the use of automated synthesizers and cassettes in the methods.
• US9452985B2
  申请人：——

  公开号：US9452985B2

  公开（公告）日：2016-09-27
• US9701637B2
  申请人：——

  公开号：US9701637B2

  公开（公告）日：2017-07-11