2-[4-(1-aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-a]pyrazine-6-carboxamide | 1447364-27-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(1-aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-a]pyrazine-6-carboxamide
• 英文别名: 2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-a]pyrazine-6-carboxamide
• CAS: 1447364-27-3
• 化学式: C₂₃H₂₁N₅O
• 分子量: 383.453
• InChiKey: RCXXWPWABQAPJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  99.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-(2-苯基乙酰基)苯基)环丁基氨基甲酸叔丁酯 在 盐酸 、 pyridinium hydrobromide perbromide 、 氨 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 二氯甲烷 为溶剂， 反应 5.5h， 生成 2-[4-(1-aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-a]pyrazine-6-carboxamide
  参考文献：
  名称：

  [EN] SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS
  [FR] IMIDAZOPYRAZINES SUBSTITUÉES UTILISÉES COMME INHIBITEURS DE L'AKT KINASE

  摘要：

  式(I)的化合物，是Pi3K/Akt通路的有效抑制剂，其生产过程及其作为药物的用途。

  公开号：

  WO2013104610A1

文献信息

• SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS
  申请人：Bayer Intellectual Property GmbH

  公开号：US20150005309A1

  公开（公告）日：2015-01-01

  Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.

  化学式为(I)的化合物是有效的Pi3K/Akt通路抑制剂，其制备过程以及作为药物的用途。
• Substituted imidazopyrazines as Akt kinase inhibitors
  申请人：Bayer Intellectual Property GmbH

  公开号：US09260435B2

  公开（公告）日：2016-02-16

  Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.

  式(I)的化合物是有效的Pi3K/Akt途径抑制剂，其制备过程和作为药物的用途。
• EP3125920B1
  申请人：——

  公开号：EP3125920B1

  公开（公告）日：2020-12-23
• COMBINATION OF ANALOGS OR DERIVATIVES OF DIANHYDROGALACTITOL WITH PLATINUM-CONTAINING ANTINEOPLASTIC AGENTS TO TREAT CANCER
  申请人：Delmar Pharmaceuticals, Inc.

  公开号：EP3294284A1

  公开（公告）日：2018-03-21
• USE OF DIANHYDROGALACTITOL AND ANALOGS OR DERIVATIVES THEREOF IN COMBINATION WITH PLATINUM-CONTAINING ANTINEOPLASTIC AGENTS TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND BRAIN METASTASES
  申请人：Del Mar Pharmaceuticals

  公开号：US20160008316A1

  公开（公告）日：2016-01-14

  The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and ovarian cancer, as well as other types of malignancy, including brain metastases of NSCLC. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N 7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide, cisplatin, and tyrosine kinase inhibitors; the drug acts independently of the MGMT repair mechanism. Dianhydrogalactitol can be used together with other anti-neoplastic agents and can possess additive or super-additive effects.