(3-hydroxyphenyl)(4-(3-hydroxyphenyl)-1H-imidazol-2-yl)methanone | 1420388-33-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3-hydroxyphenyl)(4-(3-hydroxyphenyl)-1H-imidazol-2-yl)methanone
• 英文别名: (3-hydroxyphenyl)-[5-(3-hydroxyphenyl)-1H-imidazol-2-yl]methanone
• CAS: 1420388-33-5
• 化学式: C₁₆H₁₂N₂O₃
• 分子量: 280.283
• InChiKey: NKIPXBQGBJEZND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-叠氮基-1-(3-羟基苯基)乙酮 在 potassium ethyl xanthogenate 作用下， 以 异丙醇 为溶剂， 反应 6.0h， 生成 (3-hydroxyphenyl)(4-(3-hydroxyphenyl)-1H-imidazol-2-yl)methanone 、 (3-hydroxyphenyl)(4-(3-hydroxyphenyl)-1H-imidazol-2-yl)methanone
  参考文献：
  名称：

  One-pot synthesis of disubstituted imidazole derivatives from α-azido ketones catalyzed by potassium ethylxanthate

  摘要：

  An efficient, novel procedure for the synthesis of new imidazole derivatives from alpha-azido ketones is described. This reaction proceeds via dimerization of aryl glyoxal imino generated from alpha-azido ketones in the presence of potassium ethylxanthate as a catalyst. A possible mechanism for the entire sequence is proposed. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.01.042

文献信息

• One-pot synthesis of disubstituted imidazole derivatives from α-azido ketones catalyzed by potassium ethylxanthate
  作者：Jun Chen、Wenteng Chen、Yongping Yu、Guolin Zhang

  DOI：10.1016/j.tetlet.2013.01.042

  日期：2013.3

  An efficient, novel procedure for the synthesis of new imidazole derivatives from alpha-azido ketones is described. This reaction proceeds via dimerization of aryl glyoxal imino generated from alpha-azido ketones in the presence of potassium ethylxanthate as a catalyst. A possible mechanism for the entire sequence is proposed. (c) 2013 Elsevier Ltd. All rights reserved.