2-benzoyl-1-hydroxy-4,5-dimethylimidazole | 1198220-39-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-benzoyl-1-hydroxy-4,5-dimethylimidazole
• 英文别名: 2-Benzoyl-1-hydroxy-4,5-dimethylimidazole；(1-hydroxy-4,5-dimethylimidazol-2-yl)-phenylmethanone
• CAS: 1198220-39-1
• 化学式: C₁₂H₁₂N₂O₂
• 分子量: 216.239
• InChiKey: GWYNTZMSFDUBJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-benzoylmethylidene-N-(2-hydroxyimino-1-methylpropyl)amine N-oxide 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 以84%的产率得到2-benzoyl-1-hydroxy-4,5-dimethylimidazole
  参考文献：
  名称：

  Synthesis of 2-aroyl-1-hydroxy-4,5-dimethylimidazoles by reaction of 3-hydroxyamino-2-butanone oxime with arylglyoxals*

  摘要：

  Treatment of the acetate of 3-hydroxyamino-2-butanone oxime with arylglyoxals gives alpha-aroylnitrones which cyclize under acid catalyzed conditions to form principally 2-aroyl-1-hydroxy-4,5-dimethylimidazoles. An X-ray structural analysis of 2-benzoyl-1-hydroxy-4,5-dimethylimidazole has been carried out.

  DOI：

  10.1007/s10593-009-0329-0

文献信息

• Synthesis of 2-aroyl-1-hydroxy-4,5-dimethylimidazoles by reaction of 3-hydroxyamino-2-butanone oxime with arylglyoxals*
  作者：S. A. Amitina、A. Ya. Tikhonov、I. A. Grigor’ev、Yu. V. Gatilov、B. A. Selivanov

  DOI：10.1007/s10593-009-0329-0

  日期：2009.6

  Treatment of the acetate of 3-hydroxyamino-2-butanone oxime with arylglyoxals gives alpha-aroylnitrones which cyclize under acid catalyzed conditions to form principally 2-aroyl-1-hydroxy-4,5-dimethylimidazoles. An X-ray structural analysis of 2-benzoyl-1-hydroxy-4,5-dimethylimidazole has been carried out.