8-methyl-3,4-dihydroisoquinoline 2-Oxide | 1403962-83-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: 8-methyl-3,4-dihydroisoquinoline 2-Oxide
• 英文别名: 8-Methyl-2-oxido-3,4-dihydroisoquinolin-2-ium；8-methyl-2-oxido-3,4-dihydroisoquinolin-2-ium
• CAS: 1403962-83-3
• 化学式: C₁₀H₁₁NO
• 分子量: 161.203
• InChiKey: SFVBERVLXKCTPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  28.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  异氰酸叔丁酯 、 8-methyl-3,4-dihydroisoquinoline 2-Oxide 在 三甲基氯硅烷 作用下， 以 乙腈 为溶剂， 反应 0.17h， 以64%的产率得到N-(tert-butyl)-2-hydroxy-8-methyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamide
  参考文献：
  名称：

  Chlorosilane-Promoted Addition Reaction of Isocyanides to 3,4-Dihydroisoquinoline N-Oxides

  摘要：

  The addition reaction Of isocyanides to 3,4-dihydroisoquindline N-oxides in the presence of TMSCl has been demonstrated, with the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylamides being obtained in moderate to high yields. A wide range of 3,4-dihydroisoquinoline N-oxides and isocyanides were applicable to this reaction.

  DOI：

  10.1021/jo301791m
• 作为产物：
  描述：

  2-(2-bromoethyl)-6-methylbenzaldehyde 在 盐酸羟胺 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以71%的产率得到8-methyl-3,4-dihydroisoquinoline 2-Oxide
  参考文献：
  名称：

  Chlorosilane-Promoted Addition Reaction of Isocyanides to 3,4-Dihydroisoquinoline N-Oxides

  摘要：

  The addition reaction Of isocyanides to 3,4-dihydroisoquindline N-oxides in the presence of TMSCl has been demonstrated, with the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylamides being obtained in moderate to high yields. A wide range of 3,4-dihydroisoquinoline N-oxides and isocyanides were applicable to this reaction.

  DOI：

  10.1021/jo301791m

文献信息

• Chlorosilane-Promoted Addition Reaction of Isocyanides to 3,4-Dihydroisoquinoline <i>N</i>-Oxides
  作者：Takahiro Soeta、Shuhei Fujinami、Yutaka Ukaji

  DOI：10.1021/jo301791m

  日期：2012.11.2

  The addition reaction Of isocyanides to 3,4-dihydroisoquindline N-oxides in the presence of TMSCl has been demonstrated, with the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylamides being obtained in moderate to high yields. A wide range of 3,4-dihydroisoquinoline N-oxides and isocyanides were applicable to this reaction.