3-乙氧基-1,2,4,5-四氟苯 | 42099-81-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 3-乙氧基-1,2,4,5-四氟苯
• 英文名称: 1-ethoxy-2,3,5,6-tetrafluoro-benzene
• 英文别名: 3-ethoxy-1,2,4,5-tetrafluorobenzene；1-Ethoxy-2.3.5.6-tetrafluor-benzol；1-Aethoxy-2,3,5,6-tetrafluorbenzol；EtO-p-C6F4H；2,3,5,6-tetrafluoro-ethoxybenzene；1-Ethoxy-2,3,5,6-tetrafluorobenzene
• CAS: 42099-81-0
• 化学式: C₈H₆F₄O
• mdl: MFCD18641863
• 分子量: 194.129
• InChiKey: FHOOEXUEWXMTKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  对溴甲苯 、 3-乙氧基-1,2,4,5-四氟苯 在 palladium diacetate di-tert-butyl(methyl)phosphonium tetrafluoroborate salt 、 potassium carbonate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 以89%的产率得到1-ethoxy-2,3,5,6-tetrafluoro-4′-methylbiphenyl
  参考文献：
  名称：

  Catalytic Intermolecular Direct Arylation of Perfluorobenzenes

  摘要：

  Penta-, tetra-, tri-, and difluorobenzenes undergo direct arylation with a wide range of arylhalides in high yield. Inverse reactivity is observed compared to the common electrophilic aromatic substitution pathway since electron-deficient, C-H acidic arenes react preferentially. Computational studies indicate that C-H bond cleavage occurs via a concerted carbon-palladium and carbon-hydrogen bond cleaving event involving a carbonate or a bromide ligand. The reactions are rapid, require only a slight excess of the perfluoroarene reagent, and utilize commercially available, air-stable catalyst precursors.

  DOI：

  10.1021/ja062509l
• 作为产物：
  描述：

  五氟苯 、 sodium ethanolate 以 乙醇 为溶剂， 反应 1.0h， 以3%的产率得到3-乙氧基-1,2,4,5-四氟苯
  参考文献：
  名称：

  某些氟代芳烃与乙醇根阴离子的反应

  摘要：

  乙醇钠在乙醇中与各种氟代芳烃，C 6 F 6-n H n，C 6 F 5-n H n NO 2，C 6 F 5 X（X = CF 3，C 6 F 5，COCH 3， CH 2溴），C 6氯6和mH 2 ç 6氯4进行了研究。观察到芳族卤素的部分取代。这些新产品已通过元素分析，NMR（H-1和F-19），红外光谱和质谱进行了表征。

  DOI：

  10.1016/s0022-1139(00)80901-x

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2022133281A1

  公开（公告）日：2022-06-23

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral gp120 receptor (e.g., temsavir, BMS-818251, DMJ-ll-121, BNM-IV-147, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin- binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., HIV infections).

  用于治疗病毒感染的组合物和方法包括含有病毒gp120受体抑制剂（例如，temsavir、BMS-818251、DMJ-ll-121、BNM-IV-147或其类似物）的共轭物，与Fc单体、Fc结构域和Fc结合肽、白蛋白蛋白质或白蛋白结合肽相连。特别是，这些共轭物可用于治疗病毒感染（例如，HIV感染）。
• NOVEL CASPASE INHIBITORS
  申请人：RIJKSUNIVERSITEIT GRONINGEN

  公开号：EP3666769A1

  公开（公告）日：2020-06-17

  The present invention provides novel compounds of formula (I) that are potent and selective non-covalent caspase inhibitors. These compounds nay be used for the treatment of inflammatory diseases.

  本发明提供了新型的式 (I) 化合物，它们是强效和选择性的非共价 Caspase 抑制剂。这些化合物可用于治疗炎症性疾病。
• Oligosaccharides comprising an aminooxy group and conjugates thereof
  申请人：Genzyme Corporation

  公开号：US10907142B2

  公开（公告）日：2021-02-02

  The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.

  本发明提供了包含氨基氧基的低聚糖的合成方法。本发明进一步提供了包含氨基氧基的低聚糖、将包含氨基氧基的低聚糖与糖蛋白偶联的方法，以及低聚糖-蛋白共轭物。此外，还提供了通过服用寡糖-蛋白共轭物治疗哺乳动物溶酶体贮积症的方法。
• Synthesis and Characterization of Gold(I) Complexes with 9‐(4‐Isocyanophenyl)carbazole or 9‐Ethyl‐3‐isocyanocarbazole Ligands
  作者：Rut Benavente、Pablo Espinet、Sergio Lentijo、Jose M. Martín‐Álvarez、Jesús A. Miguel、M. Paz Rodríguez‐Medina

  DOI：10.1002/ejic.200900692

  日期：2009.12

  AbstractThe carbazole derivatives 9‐(4‐isocyanophenyl)carbazole, 3,6‐dibromo‐9‐(4‐isocyanophenyl)carbazole, and 9‐ethyl‐3‐isocyanocarbazole were prepared and used to synthesize [AuX(CN‐carbazole)] (X = Cl, C6F5, C6F4‐OEt‐p) gold complexes. The X‐ray structures of [Au(C6F4‐OEt‐p)9‐(4‐isocyanophenyl)carbazole}] and [Au(C6F5)(9‐ethyl‐3‐isocyanocarbazole)], and the luminescent properties of the ligands and the complexes in the solid state, in solution at room temperature, and in frozen solution of chloroform at 77 K were determined. All the gold complexes show a redshift in the emissions relative to that of the free ligand. The presence of electron‐withdrawing substituents in 3,6‐dibromo‐9‐(4‐isocyanophenyl)carbazole quenches the luminescence, but with the introduction of a gold atom some luminescence is recovered.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
• Reaction of polyfluorinated chalcones with guanidine
  作者：E. A. Borodina、N. A. Orlova、Yu. V. Gatilov、O. I. Sal’nikova

  DOI：10.1134/s1070428015120143

  日期：2015.12

  Reactions of polyfluorinated chalcones with guanidine in the presence of bases are accompanied by elimination of the polyfluorophenyl group. 3-(Pentafluorophenyl)-1-phenylprop-2-en-1-one and its derivatives reacted with guanidine under basic conditions to give 4-phenylpyrimidin-2-amine, polyfluorobenzenes, and Michael adducts, 3-(2-amino-4-phenylpyrimidin-5-yl)-3-(4-R-2,3,5,6-tetrafluorophenyl)-1-phenylpropan-1-ones. 1-(Pentafluorophenyl)-3-phenylprop-2-en-1-one and 1,3-bis(pentafluorophenyl)prop-2-en-1-one were converted into cinnamic acid derivatives whose reaction with guanidine afforded 2-amino-6-aryl-5,6-dihydropyrimidin-4(1H)-ones.