1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[5-(hydroxymethyl)-1H-pyrazol-3-yl]urea | 1415484-35-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[5-(hydroxymethyl)-1H-pyrazol-3-yl]urea
• CAS: 1415484-35-3
• 化学式: C₁₉H₂₄N₆O₂
• 分子量: 368.439
• InChiKey: WQBOPYHAIOMYCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (3-氨基-1H-吡唑-5-基)甲醇 、 苯基(3-(叔-丁基)-1-(P-甲苯基)-1H-吡唑-5-基)氨基甲酯 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[5-(hydroxymethyl)-1H-pyrazol-3-yl]urea
  参考文献：
  名称：

  Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

  摘要：

  Previous drug discovery efforts identified classical PYK2 kinase inhibitors such as 2 and 3 that possess selectivity for PYK2 over its intra-family isoform FAK. Efforts to identify more kinome-selective chemical matter that stabilize a DFG-out conformation of the enzyme are described herein. Two sub-series of PYK2 inhibitors, an indole carboxamide-urea and a pyrazole-urea have been identified and found to have different binding interactions with the hinge region of PYK2. These leads proved to be more selective than the original classical inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.039