2-(3-Iodoprop-2-en-1-yl)-2-methyl-1,3-dioxolane | 924881-87-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(3-Iodoprop-2-en-1-yl)-2-methyl-1,3-dioxolane
• 英文别名: 2-(3-iodoprop-2-enyl)-2-methyl-1,3-dioxolane
• CAS: 924881-87-8
• 化学式: C₇H₁₁IO₂
• 分子量: 254.068
• InChiKey: VXIHBERNJSZDIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3-Iodoprop-2-en-1-yl)-2-methyl-1,3-dioxolane 、 (7a-methyl-1,5-dioxo-octahydro-inden-4-yloxy)-acetaldehyde 在 chromium dichloride 、 nickel dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  Enantioselective synthesis of (8S,13S,14R)-7-oxa-estra-4,9-diene-3,17-dione

  摘要：

  The first enantioselective synthesis of (8S,13S,14R)-7-oxa-estra-4,9-diene-3,17-dione with the trans-C/D ring junction is described. Key features of the synthesis include Ag2O-mediated C-O bond formation, thermodynamically controlled axial-equatorial inversion, one-pot of halogen exchange and Co/Cr-mediated C-C bond formation, and intramolecular aldol condensations. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.042

文献信息

• Enantioselective synthesis of (8S,13S,14R)-7-oxa-estra-4,9-diene-3,17-dione
  作者：Fu-An Kang、Nareshkumar Jain、Zhihua Sui

  DOI：10.1016/j.tetlet.2006.11.042

  日期：2007.1

  The first enantioselective synthesis of (8S,13S,14R)-7-oxa-estra-4,9-diene-3,17-dione with the trans-C/D ring junction is described. Key features of the synthesis include Ag2O-mediated C-O bond formation, thermodynamically controlled axial-equatorial inversion, one-pot of halogen exchange and Co/Cr-mediated C-C bond formation, and intramolecular aldol condensations. (c) 2006 Elsevier Ltd. All rights reserved.