4-methyl-oxonane-2,7-dione | 528870-65-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4-methyl-oxonane-2,7-dione
• 英文别名: 4-Methyloxonane-2,7-dione；4-methyloxonane-2,7-dione
• CAS: 528870-65-7
• 化学式: C₉H₁₄O₃
• 分子量: 170.208
• InChiKey: JDHDRTOAOSHYKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (3aα,6α,7aα)-6-methyloctahydrobenzofuran-3a-ol 在 ruthenium trichloride 、 sodium periodate 作用下， 以 四氯化碳 、 乙腈 为溶剂， 反应 1.25h， 以55%的产率得到4-methyl-oxonane-2,7-dione
  参考文献：
  名称：

  Efficient Entry into Medium-Ring Keto-Lactones. The Ruthenium Tetraoxide-Promoted Oxidative Cleavage of β-Hydroxyethers

  摘要：

  A new use of ruthenium tetraoxide is reported. The catalytic oxidative cleavage of hexahydro-benzofuran-3a-ols led to nine-membered ring keto-lactones in moderate to good yields and high purity. The reaction is clean and easily performed using catalytic amounts of ruthenium trichloride and an excess of sodium periodate as a cooxidant.

  DOI：

  10.1021/ol0342958

文献信息

• Efficient Entry into Medium-Ring Keto-Lactones. The Ruthenium Tetraoxide-Promoted Oxidative Cleavage of β-Hydroxyethers
  作者：Helena M. C. Ferraz、Luiz S. Longo

  DOI：10.1021/ol0342958

  日期：2003.4.1

  A new use of ruthenium tetraoxide is reported. The catalytic oxidative cleavage of hexahydro-benzofuran-3a-ols led to nine-membered ring keto-lactones in moderate to good yields and high purity. The reaction is clean and easily performed using catalytic amounts of ruthenium trichloride and an excess of sodium periodate as a cooxidant.