3-[(3-Methylbutyl)amino]butan-2-one | 85061-18-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[(3-Methylbutyl)amino]butan-2-one
• 英文别名: 3-(3-methylbutylamino)butan-2-one
• CAS: 85061-18-3
• 化学式: C₉H₁₉NO
• 分子量: 157.25
• InChiKey: NQJIFYCMUZSHEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• MACROLIDES WITH MODIFIED DESOSAMINE SUGARS AND USES THEREOF
  申请人：President and Fellows of Harvard College

  公开号：US20180066008A1

  公开（公告）日：2018-03-08

  Provided herein are macrolide compounds of Formula (I) and (I-N) for the treatment of infectious diseases and inflammatory conditions. The 14-membered ketolides and 14-, 15-, and 16-membered azaketolides described herein comprise modified sugars which are desosamine or mycaminose analogs. Pharmaceutical compositions and methods of treating infection diseases and inflammatory conditions using the inventive macrolides are also provided. This disclosure additionally provides methods of preparing the macrolides by the coupling of an eastern and western half.