1-(2-chloropyridin-4-yl)-3-(2,4-difluorophenyl)urea | 847371-02-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-chloropyridin-4-yl)-3-(2,4-difluorophenyl)urea
• 英文别名: N-(2-Chloropyridin-4-yl)-N'-(2,4-difluorophenyl)urea
• CAS: 847371-02-2
• 化学式: C₁₂H₈ClF₂N₃O
• 分子量: 283.665
• InChiKey: YUOSROUVWWSLBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] UREA DERIVATIVES<br/>[FR] DÉRIVÉS D'URÉE
  申请人：BAYER AG

  公开号：WO2020126968A2

  公开（公告）日：2020-06-25

  The present invention covers urea compounds of general formula (I) in which R1, A and B are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.