3-异丙基环丁基甲醇 | 1269291-96-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-异丙基环丁基甲醇
• 英文名称: (3-Isopropylcyclobutyl)methanol
• 英文别名: (3-propan-2-ylcyclobutyl)methanol
• CAS: 1269291-96-4
• 化学式: C₈H₁₆O
• 分子量: 128.21
• InChiKey: FVHPFGGDBCIDRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-异丙基环丁基甲酸 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 生成 3-异丙基环丁基甲醇
  参考文献：
  名称：

  WO2024092039A1

  摘要：

  公开号：

文献信息

• METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20160194331A1

  公开（公告）日：2016-07-07

  The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

  本发明旨在提供一种有效生产和提供具有螺环氧吲哚骨架的化合物的方法，例如，利用不对称催化剂制备具有螺环氧吲哚骨架并具有抗肿瘤活性的化合物，该化合物抑制Mdm2蛋白与p53蛋白之间的相互作用，或其中间体。通过使用酮亚胺作为反应底物，并使用手性配体和Lewis酸进行催化不对称1,3-二极环加成反应，有效地获得具有光学活性的三环二螺吲哚骨架的化合物。
• BICYCLIC HETEROCYCLE SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE MODULATORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150274696A1

  公开（公告）日：2015-10-01

  Compounds having the following formula (I) or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R 2 is a bicyclic heterocycle, and R 1 , R 3 , R 4 , R 5 and R 6 are as defined herein, that are useful as kinase modulators, including IRAK-4 modulation.

  具有以下式(I)或其立体异构体或药物可接受的盐的化合物，其中R2是双环杂环，R1、R3、R4、R5和R6如此定义，可用作激酶调节剂，包括IRAK-4调节剂。
• Chemokine receptor modulators and uses thereof
  申请人：Rapt Therapeutics, Inc.

  公开号：US10683280B2

  公开（公告）日：2020-06-16

  Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.

  本文特别公开了用于调节某些趋化因子受体活性的化合物及其使用方法。
• Protein Kinase Inhibitors
  申请人：PHARMASCIENCE INC.

  公开号：US20160289236A1

  公开（公告）日：2016-10-06

  The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the members of the Tec or Src protein kinase families. The present invention also relates to the processes of preparation of these compounds, their intermediates, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative, inflammatory, autoimmune, or infectious diseases, disorders, or conditions in which protein kinase activity is implicated.
• CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
  申请人：FLX Bio, Inc.

  公开号：US20190233397A1

  公开（公告）日：2019-08-01

  Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.