2-(1-Hydroxy-pentyl)-thiazole-4-carboxylic acid methyl ester | 648903-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(1-Hydroxy-pentyl)-thiazole-4-carboxylic acid methyl ester
• 英文别名: Methyl 2-(1-hydroxypentyl)-1,3-thiazole-4-carboxylate；methyl 2-(1-hydroxypentyl)-1,3-thiazole-4-carboxylate
• CAS: 648903-40-6
• 化学式: C₁₀H₁₅NO₃S
• 分子量: 229.3
• InChiKey: IVFYBMALDRSGPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  87.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  正戊醛 、 3-(二甲基氨基)-2-异氰基-2-丙烯酸甲酯 、 硫代乙酸 在 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 生成 2-(1-Hydroxy-pentyl)-thiazole-4-carboxylic acid methyl ester 、 2-(1-Acetoxy-pentyl)-thiazole-4-carboxylic acid methyl ester
  参考文献：
  名称：

  Convergent multicomponent assembly of 2-acyloxymethyl thiazoles

  摘要：

  Diverse substituted 2-acyloxymethyl thiazoles can be assembled by a new multicomponent reaction (MCR) of methyl 3-(N,N-dimethylamino)-2-isocyanoacrylate, aldehydes and thiocarboxylic acid under Lewis acid catalysis. The reaction is performed under mild conditions and is compatible with a wide range of functionalized starting materials. 13 examples are given. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.012

文献信息

• Convergent multicomponent assembly of 2-acyloxymethyl thiazoles
  作者：Bernd Henkel、Barbara Beck、Benedikt Westner、Beatrice Mejat、Alexander Dömling

  DOI：10.1016/j.tetlet.2003.10.012

  日期：2003.12

  Diverse substituted 2-acyloxymethyl thiazoles can be assembled by a new multicomponent reaction (MCR) of methyl 3-(N,N-dimethylamino)-2-isocyanoacrylate, aldehydes and thiocarboxylic acid under Lewis acid catalysis. The reaction is performed under mild conditions and is compatible with a wide range of functionalized starting materials. 13 examples are given. (C) 2003 Elsevier Ltd. All rights reserved.