Microreactor Technology: Continuous Synthesis of 1<i>H</i>-Isochromeno[3,4-<i>d</i>]imidazol-5-ones
作者:Davy R. J. Acke、Christian V. Stevens、Bart I. Roman
DOI:10.1021/op700289e
日期:2008.9.19
A synthetic method was evaluated to form 1H-isochromeno[3,4-d]imidazol-5-ones via ring closure starting from 3-amino-4-(aryl-amino)-1H-isochromen-1-ones. The method was implemented and optimized in a microreactor environment. It was possible to synthesize these compounds in a continuous mode with an output up to 2.2 g/h.